Buerger disease

General Information (adopted from Orphanet):

Synonyms, Signs: thromboangiitis obliterans
Number of Symptoms 17
OrphanetNr: 36258
OMIM Id: 211480
ICD-10: I73.1
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: 16 of 100 000 [Orphanet]
Inheritance: Autosomal recessive inheritance
[Omim]
Age of onset: Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Predominantly medium-vessel vasculitis
 -Rare circulatory system disease
 -Rare systemic or rheumatologic disease
Secondary glomerular disease
 -Rare renal disease

Symptom Information: Sort by abundance 

1
 (HPO:0001357) Plagiocephaly Occasional [Orphanet] 106 / 7739
2
 (HPO:0000763) Sensory neuropathy Frequent [Orphanet] 78 / 7739
3
 (HPO:0100785) Insomnia Occasional [Orphanet] 18 / 7739
4
 (HPO:0003474) Sensory impairment Frequent [Orphanet] 54 / 7739
5
 (HPO:0012531) Pain 9 / 7739
6
 (HPO:0009763) Limb pain 7 / 7739
7
 (HPO:0005059) Arthralgia/arthritis Frequent [Orphanet] 141 / 7739
8
 (HPO:0200042) Skin ulcer Very frequent [Orphanet] 138 / 7739
9
 (HPO:0001063) Acrocyanosis Frequent [Orphanet] 56 / 7739
10
 (HPO:0000975) Hyperhidrosis 64 / 7739
11
 (HPO:0012089) Arteritis Very frequent [Orphanet] 40 / 7739
12
 (HPO:0004420) Arterial thrombosis Very frequent [Orphanet] 20 / 7739
13
 (HPO:0100758) Gangrene Very frequent [Orphanet] 25 / 7739
14
 (OMIM) Coldness 1 / 7739
15
 (OMIM) Red, elevated areas over venous valves 1 / 7739
16
 (OMIM) Hyperhydrosis 2 / 7739
17
 (HPO:0000007) Autosomal recessive inheritance 2538 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: