Syndactyly - camptodactyly and clinodactyly of fifth fingers - bifid toes

General Information (adopted from Orphanet):

Synonyms, Signs: CAMPTODACTYLY, CLINODACTYLY, SYNDACTYLY, AND BIFID TOE SYNDROME
Wahab syndrome
Synactyly - camptodactyly and clinodactyly of fifth fingers - bifid halluces
Number of Symptoms 28
OrphanetNr: 357332
OMIM Id: 615170
ICD-10: Q87.2
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal recessive
[Orphanet]
Age of onset: Neonatal
Infancy
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Syndrome with limb duplication, polydactyly, syndactyly, and/or hyperphalangy
 -Rare bone disease
 -Rare developmental defect during embryogenesis

Symptom Information: Sort by abundance 

1
 (HPO:0004279) Short palm 323 / 7739
2
 (HPO:0012385) Camptodactyly 113 / 7739
3
 (HPO:0009778) Short thumb 50 / 7739
4
 (HPO:0010049) Short metacarpal 99 / 7739
5
 (HPO:0004242) Broad carpal bones 1 / 7739
6
 (HPO:0001773) Short foot 86 / 7739
7
 (HPO:0001159) Syndactyly 140 / 7739
8
 (HPO:0001181) Adducted thumb 31 / 7739
9
 (OMIM) Dysplasia of middle/distal phalangeal bones 1 / 7739
10
 (OMIM) Severe syndactyly 1 / 7739
11
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739
12
 (OMIM) Fused fingernails 2 / 7739
13
 (OMIM) Malformed fingernails 1 / 7739
14
 (HPO:0030084) Clinodactyly 90 / 7739
15
 (OMIM) Camptodactyly of 5th fingers 1 / 7739
16
 (OMIM) Clinodactyly of 5th fingers 2 / 7739
17
 (OMIM) Synpolydactyly 2 / 7739
18
 (OMIM) Rudimentary terminal phalanx 1 / 7739
19
 (OMIM) Short carpal bones 1 / 7739
20
 (OMIM) Mesoaxial camptodactyly (2nd, 2/3, or 2/3/4 toes) 1 / 7739
21
 (OMIM) Symphalangism of the DIP joint 1 / 7739
22
 (OMIM) Total cutaneous webbing 1 / 7739
23
 (OMIM) Ulnar deviation of 3rd fingers 1 / 7739
24
 (OMIM) Bifid 5th toe 1 / 7739
25
 (OMIM) Ankylosis of tarsometatarsal joint 1 / 7739
26
 (OMIM) 2nd metacarpal exostosis 1 / 7739
27
 (OMIM) Broad metacarpal bones 2 / 7739
28
 (OMIM) Bifid hallux 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Malik et al. (2010) described a 5-generation Pakistani kindred in which 26 members had a unique combination of camptodactyly and clinodactyly of 5th fingers, mesoaxial camptodactyly of toes, ulnar deviation of 3rd fingers, syndactyly involving all digits, and ...