Worster-Drought syndrome

General Information (adopted from Orphanet):

Synonyms, Signs: WORSTER-DROUGHT SYNDROME
Congenital suprabulbar paresis
Number of Symptoms 17
OrphanetNr: 3465
OMIM Id: 185480
ICD-10: G80.8
UMLs: C0796204
MeSH: C536747
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: 3.7 of 100 000 [Orphanet]
Inheritance: Autosomal dominant
Not applicable
[Orphanet]
Age of onset: Childhood
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Rare neurologic disease
 -Rare neurologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0002307) Drooling 43 / 7739
2
 (HPO:0000252) Microcephaly Occasional [Orphanet] 832 / 7739
3
 (HPO:0000407) Sensorineural hearing impairment Occasional [Orphanet] 524 / 7739
4
 (HPO:0001250) Seizures Occasional [Orphanet] 1245 / 7739
5
 (HPO:0001249) Intellectual disability 1089 / 7739
6
 (HPO:0001260) Dysarthria 329 / 7739
7
 (HPO:0001347) Hyperreflexia Frequent [Orphanet] 363 / 7739
8
 (HPO:0002167) Neurological speech impairment Very frequent [Orphanet] 308 / 7739
9
 (HPO:0004374) Hemiplegia/hemiparesis Occasional [Orphanet] 158 / 7739
10
 (HPO:0002353) EEG abnormality 188 / 7739
11
 (HPO:0001291) Abnormality of the cranial nerves Very frequent [Orphanet] 27 / 7739
12
 (HPO:0001324) Muscle weakness 859 / 7739
13
 (OMIM) Tongue and soft palate weakness 1 / 7739
14
 (OMIM) Congenital suprabulbar paresis 1 / 7739
15
 (OMIM) Orbicularis oris muscle weakness 1 / 7739
16
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739
17
 (HPO:0012758) Neurodevelopmental delay Frequent [Orphanet] 949 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: