Chronic recurrent multifocal osteomyelitis

General Information (adopted from Orphanet):

Synonyms, Signs: OSTEOMYELITIS, CHRONIC MULTIFOCAL
CRMO
CMO
Number of Symptoms 33
OrphanetNr: 324964
OMIM Id: 259680
ICD-10: M86.3
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Not applicable
[Orphanet]
Age of onset: Childhood
Adolescent
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Autoinflammatory syndrome with skin involvement
 -Rare skin disease
Pyogenic autoinflammatory syndrome
 -Rare systemic or rheumatologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0006824) Cranial nerve paralysis Occasional [Orphanet] 81 / 7739
2
 (HPO:0009830) Peripheral neuropathy Occasional [Orphanet] 206 / 7739
3
 (HPO:0003468) Abnormality of the vertebrae Frequent [Orphanet] 77 / 7739
4
 (HPO:0002754) Osteomyelitis Very frequent [Orphanet] 37 / 7739
5
 (HPO:0100781) Abnormality of the sacroiliac joint Occasional [Orphanet] 6 / 7739
6
 (HPO:0002653) Bone pain Very frequent [Orphanet] 75 / 7739
7
 (HPO:0002650) Scoliosis Occasional [Orphanet] 705 / 7739
8
 (HPO:0100774) Hyperostosis Very frequent [Orphanet] 17 / 7739
9
 (HPO:0005901) Chronic recurrent multifocal osteomyelitis 1 / 7739
10
 (HPO:0005930) Abnormality of epiphysis morphology Frequent [Orphanet] 119 / 7739
11
 (HPO:0100769) Synovitis Frequent [Orphanet] 86 / 7739
12
 (HPO:0002797) Osteolysis Frequent [Orphanet] 68 / 7739
13
 (HPO:0000944) Abnormality of the metaphyses Frequent [Orphanet] 141 / 7739
14
 (HPO:0011001) Increased bone mineral density Frequent [Orphanet] 78 / 7739
15
 (HPO:0002037) Inflammation of the large intestine Occasional [Orphanet] 25 / 7739
16
 (HPO:0004325) Decreased body weight Frequent [Orphanet] 492 / 7739
17
 (HPO:0003765) Psoriasis Occasional [Orphanet] 17 / 7739
18
 (HPO:0100838) Recurrent cutaneous abscess formation Frequent [Orphanet] 15 / 7739
19
 (HPO:0001061) Acne Occasional [Orphanet] 33 / 7739
20
 (HPO:0000989) Pruritus Occasional [Orphanet] 111 / 7739
21
 (HPO:0000988) Skin rash Occasional [Orphanet] 98 / 7739
22
 (HPO:0100847) Palmoplantar pustulosis Occasional [Orphanet] 2 / 7739
23
 (HPO:0012089) Arteritis Occasional [Orphanet] 40 / 7739
24
 (HPO:0002624) Venous abnormality Occasional [Orphanet] 2 / 7739
25
 (HPO:0001903) Anemia Occasional [Orphanet] 289 / 7739
26
 (HPO:0001945) Fever Occasional [Orphanet] 218 / 7739
27
 (HPO:0011227) Elevated C-reactive protein level Frequent [Orphanet] 55 / 7739
28
 (HPO:0001939) Abnormality of metabolism/homeostasis 328 / 7739
29
 (HPO:0000969) Edema Frequent [Orphanet] 117 / 7739
30
 (HPO:0001324) Muscle weakness Frequent [Orphanet] 859 / 7739
31
 (OMIM) No pathogens isolated from affected areas 1 / 7739
32
 (OMIM) Long bone metaphyses predominantly involved 1 / 7739
33
 (OMIM) Subacute and chronic inflammatory histologic features 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Giedion et al. (1972) described a syndrome termed chronic recurrent multifocal osteomyelitis (CRMO). The inflammation had both subacute and chronic features, with lesions located predominantly in the metaphyses of the long bones. No pathogens were isolated from affected ...