White matter hypoplasia - corpus callosum agenesis - intellectual deficit

General Information (adopted from Orphanet):

Synonyms, Signs: Curatolo-Cilio-Pessagno syndrome
Number of Symptoms 16
OrphanetNr: 3207
OMIM Id:
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: Rare genetic intellectual deficit with developmental anomaly
 -Rare genetic disease
Rare intellectual deficit with developmental anomaly
 -Rare neurologic disease
Syndrome with corpus callosum agenesis /dysgenesis as a major feature
 -Rare developmental defect during embryogenesis
 -Rare neurologic disease

Symptom Information: Sort by abundance 

1
(HPO:0000316) Hypertelorism Very frequent [Orphanet] 644 / 7739
2
(HPO:0002007) Frontal bossing Very frequent [Orphanet] 366 / 7739
3
(HPO:0000664) Synophrys Frequent [Orphanet] 112 / 7739
4
(HPO:0000431) Wide nasal bridge Very frequent [Orphanet] 290 / 7739
5
(HPO:0000494) Downslanted palpebral fissures Frequent [Orphanet] 328 / 7739
6
(HPO:0000277) Abnormality of the mandible Very frequent [Orphanet] 394 / 7739
7
(HPO:0000252) Microcephaly Very frequent [Orphanet] 832 / 7739
8
(HPO:0001347) Hyperreflexia Very frequent [Orphanet] 363 / 7739
9
(HPO:0001172) Abnormality of the thumb Occasional [Orphanet] 103 / 7739
10
(HPO:0004322) Short stature Very frequent [Orphanet] 1232 / 7739
11
(HPO:0001252) Muscular hypotonia Very frequent [Orphanet] 990 / 7739
12
(HPO:0002119) Ventriculomegaly Frequent [Orphanet] 253 / 7739
13
(HPO:0002334) Abnormality of the cerebellar vermis Frequent [Orphanet] 137 / 7739
14
(HPO:0007370) Aplasia/Hypoplasia of the corpus callosum Very frequent [Orphanet] 180 / 7739
15
(HPO:0012758) Neurodevelopmental delay Very frequent [Orphanet] 949 / 7739
16
(HPO:0002120) Cerebral cortical atrophy Very frequent [Orphanet] 187 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: