Rheumatic fever
General Information (adopted from Orphanet):
| Synonyms, Signs: |
Acute rheumatic fever |
| Number of Symptoms | 37 |
| OrphanetNr: | 3099 |
| OMIM Id: |
268240
|
| ICD-10: |
I00 I01 |
| UMLs: |
C0035436 |
| MeSH: |
D012213 |
| MedDRA: |
10039054 |
| Snomed: |
26424001 58718002 |
Prevalence, inheritance and age of onset:
| Prevalence: | No data available. |
| Inheritance: |
Not applicable [Orphanet] |
| Age of onset: |
Childhood [Orphanet] |
Disease classification (adopted from Orphanet):
| Parent Diseases: |
Rare systemic disease
-Rare systemic or rheumatologic disease |
Symptom Information:
|
|
(HPO:0000100) | Nephrotic syndrome | Occasional [Orphanet] | 83 / 7739 | |||
|
|
(HPO:0100776) | Recurrent pharyngitis | Very frequent [Orphanet] | 18 / 7739 | |||
|
|
(HPO:0000421) | Epistaxis | Occasional [Orphanet] | 85 / 7739 | |||
|
|
(HPO:0000246) | Sinusitis | Frequent [Orphanet] | 73 / 7739 | |||
|
|
(HPO:0004305) | Involuntary movements | Occasional [Orphanet] | 50 / 7739 | |||
|
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(HPO:0002167) | Neurological speech impairment | Occasional [Orphanet] | 308 / 7739 | |||
|
|
(HPO:0100248) | Hemiballismus | Occasional [Orphanet] | 1 / 7739 | |||
|
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(HPO:0000708) | Behavioral abnormality | Occasional [Orphanet] | 212 / 7739 | |||
|
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(HPO:0002315) | Headache | Occasional [Orphanet] | 175 / 7739 | |||
|
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(HPO:0001288) | Gait disturbance | Occasional [Orphanet] | 318 / 7739 | |||
|
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(HPO:0005059) | Arthralgia/arthritis | Frequent [Orphanet] | 141 / 7739 | |||
|
|
(HPO:0100749) | Chest pain | Frequent [Orphanet] | 92 / 7739 | |||
|
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(HPO:0100769) | Synovitis | Very frequent [Orphanet] | 86 / 7739 | |||
|
|
(HPO:0002017) | Nausea and vomiting | Very frequent [Orphanet] | 134 / 7739 | |||
|
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(HPO:0002019) | Constipation | Occasional [Orphanet] | 194 / 7739 | |||
|
|
(HPO:0002039) | Anorexia | Very frequent [Orphanet] | 62 / 7739 | |||
|
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(HPO:0010318) | Aplasia/Hypoplasia of the abdominal wall musculature | Occasional [Orphanet] | 55 / 7739 | |||
|
|
(HPO:0002027) | Abdominal pain | Frequent [Orphanet] | 184 / 7739 | |||
|
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(HPO:0010783) | Erythema | Very frequent [Orphanet] | 138 / 7739 | |||
|
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(HPO:0001031) | Subcutaneous lipoma | Very frequent [Orphanet] | 112 / 7739 | |||
|
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(HPO:0000980) | Pallor | Frequent [Orphanet] | 52 / 7739 | |||
|
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(HPO:0001633) | Abnormality of the mitral valve | Frequent [Orphanet] | 69 / 7739 | |||
|
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(HPO:0001697) | Abnormality of the pericardium | Occasional [Orphanet] | 52 / 7739 | |||
|
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(HPO:0001654) | Abnormality of the heart valves | Occasional [Orphanet] | 49 / 7739 | |||
|
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(HPO:0004306) | Abnormality of the endocardium | Frequent [Orphanet] | 24 / 7739 | |||
|
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(HPO:0001646) | Abnormality of the aortic valve | Frequent [Orphanet] | 55 / 7739 | |||
|
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(HPO:0011675) | Arrhythmia | Frequent [Orphanet] | 226 / 7739 | |||
|
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(HPO:0001637) | Abnormality of the myocardium | Frequent [Orphanet] | 76 / 7739 | |||
|
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(HPO:0001945) | Fever | Very frequent [Orphanet] | 218 / 7739 | |||
|
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(HPO:0011227) | Elevated C-reactive protein level | Very frequent [Orphanet] | 55 / 7739 | |||
|
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(HPO:0002093) | Respiratory insufficiency | Occasional [Orphanet] | 410 / 7739 | |||
|
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(HPO:0002103) | Abnormality of the pleura | Occasional [Orphanet] | 58 / 7739 | |||
|
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(HPO:0002715) | Abnormality of the immune system | 46 / 7739 | ||||
|
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(HPO:0001324) | Muscle weakness | Frequent [Orphanet] | 859 / 7739 | |||
|
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(MedDRA:10025421) | Macule | Very frequent [Orphanet] | 55 / 7739 | |||
|
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(OMIM) | Increased frequency of B cells with 883 antigen | 1 / 7739 | ||||
|
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(OMIM) | Predisposition to rheumatic fever | 1 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
|---|