Allergic bronchopulmonary aspergillosis

General Information (adopted from Orphanet):

Synonyms, Signs: ABPA
Allergic aspergillosis
Hinson-Pepys disease
Number of Symptoms 14
OrphanetNr: 1164
OMIM Id: 103920
ICD-10: B44.1
UMLs: C0004031
MeSH: D001229
MedDRA: 10006474
Snomed: 37981002

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Not applicable
[Orphanet]
Age of onset: Childhood
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Rare allergic respiratory disease
 -Rare allergic disease
Rare pulmonary disease
 -Rare respiratory disease

Symptom Information: Sort by abundance 

1
 (HPO:0004325) Decreased body weight Frequent [Orphanet] 492 / 7739
2
 (HPO:0001231) Abnormality of the fingernails Occasional [Orphanet] 116 / 7739
3
 (HPO:0002092) Pulmonary hypertension Occasional [Orphanet] 109 / 7739
4
 (HPO:0001879) Abnormality of eosinophils Very frequent [Orphanet] 20 / 7739
5
 (HPO:0001945) Fever Frequent [Orphanet] 218 / 7739
6
 (HPO:0002099) Asthma Very frequent [Orphanet] 62 / 7739
7
 (HPO:0002105) Hemoptysis Occasional [Orphanet] 30 / 7739
8
 (HPO:0002097) Emphysema Occasional [Orphanet] 40 / 7739
9
 (HPO:0002093) Respiratory insufficiency Occasional [Orphanet] 410 / 7739
10
 (HPO:0002110) Bronchiectasis Frequent [Orphanet] 73 / 7739
11
 (HPO:0002715) Abnormality of the immune system Very frequent [Orphanet] 46 / 7739
12
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739
13
 ([DEL]MedDRA:10011224) Cough Very frequent [Orphanet] 70 / 7739
14
 (MedDRA:10006474) Bronchopulmonary aspergillosis allergic 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Graves et al. (1979) described 2 brothers with identical HLA haplotypes and allergic bronchopulmonary aspergillosis. A barn near the residence of the brothers was identified as the probable source. Vithayasai et al. (1973) also reported familial allergic aspergillosis. ...