Menetrier disease

General Information (adopted from Orphanet):

Synonyms, Signs: MENETRIER DISEASE
Giant hypertrophic gastritis
Hypoproteinemic hypertrophic gastropathy
Number of Symptoms 14
OrphanetNr: 2494
OMIM Id: 137280
ICD-10: K29.6
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant
[Orphanet]
Age of onset: Childhood
Adolescent
Adult
Elderly
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Rare gastro-esophageal disease
 -Rare gastroenterologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0002027) Abdominal pain Very frequent [Orphanet] 184 / 7739
2
 (HPO:0002039) Anorexia Frequent [Orphanet] 62 / 7739
3
 (HPO:0002017) Nausea and vomiting Very frequent [Orphanet] 134 / 7739
4
 (HPO:0002239) Gastrointestinal hemorrhage Frequent [Orphanet] 97 / 7739
5
 (HPO:0004325) Decreased body weight Frequent [Orphanet] 492 / 7739
6
 (HPO:0010741) Edema of the lower limbs Very frequent [Orphanet] 34 / 7739
7
 (HPO:0003075) Hypoproteinemia Frequent [Orphanet] 27 / 7739
8
 (HPO:0001891) Iron deficiency anemia Frequent [Orphanet] 22 / 7739
9
 (HPO:0100806) Sepsis Occasional [Orphanet] 48 / 7739
10
 (HPO:0005246) Giant hypertrophic gastritis 1 / 7739
11
 (OMIM) Enlarged gastric mucosal folds 1 / 7739
12
 (OMIM) Gastric glandular proliferation with nuclear polarity preservation and cystic dilatation of gland base 1 / 7739
13
 (OMIM) Hypochlorhydria 1 / 7739
14
 (OMIM) recessive 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Giant hypertrophic gastritis was described as a clinical entity by Menetrier (1888). It is characterized by enlargement of the gastric mucosal folds, affecting primarily the body of the stomach with frequent sparing of the gastric antrum. Histologically, there ...