Hydrops fetalis

General Information (adopted from Orphanet):

Synonyms, Signs: NIHF HYDROPS FETALIS, ALPHA-THALASSEMIA-RELATED, INCLUDED
HEMOGLOBIN H HYDROPS FETALIS SYNDROME, INCLUDED
HF
Fetal hydrops
Fetal edema
Number of Symptoms 7
OrphanetNr: 1041
OMIM Id: 236750
ICD-10: P56
P83.2
UMLs: C0020305
MeSH: D015160
MedDRA: 10020529
Snomed: 276508000

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Not applicable
[Orphanet]
Age of onset: Antenatal
Neonatal
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Rare developmental defect during embryogenesis
 -Rare developmental defect during embryogenesis

Symptom Information: Sort by abundance 

1
(HPO:0001789) Hydrops fetalis Very frequent [Orphanet] 63 / 7739
2
(HPO:0001635) Congestive heart failure 232 / 7739
3
(HPO:0001903) Anemia 289 / 7739
4
(OMIM) No maternal-fetal incompatibility 3 / 7739
5
(OMIM) Congestive heart failure at birth 3 / 7739
6
(OMIM) Edema at birth 4 / 7739
7
(OMIM) Anemia at birth 3 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Hydrops fetalis is a descriptive term for generalized edema of the fetus, with fluid accumulation in extravascular components and body cavities. It is not a diagnosis in itself, but a symptom and end-stage result of a wide variety ...
Diagnosis OMIM Based on the findings of Bellini et al. (2009), Bellini et al. (2009) provided a diagnostic flow chart for the evaluation of nonimmune hydrops fetalis.
Clinical Description OMIM Idiopathic hydrops fetalis may represent about half of all cases of hydrops fetalis of nonimmunologic origin (i.e., not due to RH blood group incompatibility (111700) or other fetal-maternal incompatibility). Schwartz et al. (1981) listed causes of nonimmunologic hydrops ...
Population genetics OMIM The estimated number of worldwide annual births of patients with Hb Bart's hydrops is 5,183 (Modell and Darlison, 2008 and Weatherall, 2010).