Congenital laryngeal web

General Information (adopted from Orphanet):

Synonyms, Signs: SUBGLOTTIC WEB
GLOTTIC WEB, CONGENITAL ANTERIOR
SUBGLOTTIC BAR
Number of Symptoms 15
OrphanetNr: 2374
OMIM Id: 150360
ICD-10: Q31.0
UMLs: C0152416
MeSH:
MedDRA: 10023871
Snomed: 47070001

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: Larynx anomaly
 -Rare developmental defect during embryogenesis
 -Rare genetic disease
 -Rare otorhinolaryngologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0002788) Recurrent upper respiratory tract infections 31 / 7739
2
 (HPO:0004322) Short stature Very frequent [Orphanet] 1232 / 7739
3
 (HPO:0004760) Congenital septal defect Very frequent [Orphanet] 69 / 7739
4
 (HPO:0001601) Laryngomalacia Very frequent [Orphanet] 61 / 7739
5
 (HPO:0001608) Abnormality of the voice Very frequent [Orphanet] 126 / 7739
6
 (HPO:0005950) Laryngeal web 5 / 7739
7
 (HPO:0010307) Stridor 19 / 7739
8
 (HPO:0001609) Hoarse voice 34 / 7739
9
 (HPO:0002093) Respiratory insufficiency Frequent [Orphanet] 410 / 7739
10
 (HPO:0002098) Respiratory distress 75 / 7739
11
 (HPO:0011420) Death Occasional [Orphanet] 184 / 7739
12
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739
13
 (OMIM) Hoarse or weak voice 1 / 7739
14
 (OMIM) Congenital anterior laryngeal (glottic) web 1 / 7739
15
 (OMIM) Unusual cry 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Congenital laryngeal (glottic) webs are uncommon, membrane-like structures that extend across the laryngeal lumen near the level of the vocal cords. They are thought to result from incomplete resorption of an epithelial layer that normally obliterates the developing ...
Clinical Description OMIM Cohen (1985) divided laryngeal (glottic) webs into 4 types based on their appearance and an estimation of the degree of airway obstruction. Type 1 glottic webs are uniform in thickness with no subglottic extension; they compromise less than ...