Tropical pancreatitis

General Information (adopted from Orphanet):

Synonyms, Signs: TCP
Tropical calcific chronic pancreatitis
Number of Symptoms 10
OrphanetNr: 103918
OMIM Id: 608189
ICD-10: K86.1
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
Autosomal recessive inheritance
[Omim]
Age of onset: Childhood
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Rare pancreatic disease
 -Rare gastroenterologic disease

Symptom Information: Sort by abundance 

1
(HPO:0008205) Insulin-dependent but ketosis-resistant diabetes 1 / 7739
2
(HPO:0005213) Pancreatic calcification 3 / 7739
3
(HPO:0006280) Chronic pancreatitis 3 / 7739
4
(HPO:0002027) Abdominal pain 184 / 7739
5
(HPO:0002894) Neoplasm of the pancreas 17 / 7739
6
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
7
(OMIM) Increased incidence of fibrocalculus pancreatic diabetes (FCPD) 1 / 7739
8
(HPO:0000007) Autosomal recessive inheritance 2538 / 7739
9
(OMIM) Recurrent abdominal pain since childhood 1 / 7739
10
(OMIM) Intraductal calculi, especially in the caput 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. Fibrocalculous pancreatic diabetes (FCPD) is a form of diabetes secondary to TCP (Mohan et al., 1989). TCP differs from alcoholic pancreatitis by ...
Molecular genetics OMIM In 68 patients from India with clinically and radiologically confirmed TCP (24 with FCPD and 44 with TCP without diabetes mellitus), Chandak et al. (2002) analyzed for mutations in the PRSS1 and SPINK1 genes. No mutation was detected ...