Dermatomyositis
General Information (adopted from Orphanet):
| Synonyms, Signs: |
DM Adult-onset dermatomyositis |
| Number of Symptoms | 47 |
| OrphanetNr: | 221 |
| OMIM Id: |
|
| ICD-10: |
M33.0 M33.1 |
| UMLs: |
C0011633 |
| MeSH: |
D003882 |
| MedDRA: |
10012503 |
| Snomed: |
396230008 |
Prevalence, inheritance and age of onset:
| Prevalence: | 17 of 100 000 [Orphanet] |
| Inheritance: |
Not applicable [Orphanet] |
| Age of onset: |
All ages [Orphanet] |
Disease classification (adopted from Orphanet):
| Parent Diseases: |
Idiopathic inflammatory myopathy
-Rare neurologic disease Secondary glomerular disease -Rare renal disease Systemic autoimmune disease -Rare systemic or rheumatologic disease Systemic disease with skin involvement -Rare skin disease |
Symptom Information:
|
|
(HPO:0100615) | Ovarian neoplasm | Occasional [Orphanet] | 25 / 7739 | |||
|
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(HPO:0000606) | Abnormality of the periorbital region | Very frequent [Orphanet] | 96 / 7739 | |||
|
|
(HPO:0002015) | Dysphagia | Occasional [Orphanet] | 301 / 7739 | |||
|
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(HPO:0002167) | Neurological speech impairment | Occasional [Orphanet] | 308 / 7739 | |||
|
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(HPO:0100013) | Neoplasm of the breast | Occasional [Orphanet] | 18 / 7739 | |||
|
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(HPO:0100769) | Synovitis | Frequent [Orphanet] | 86 / 7739 | |||
|
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(HPO:0005059) | Arthralgia/arthritis | Frequent [Orphanet] | 141 / 7739 | |||
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(HPO:0100723) | Gastrointestinal stroma tumor | Occasional [Orphanet] | 7 / 7739 | |||
|
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(HPO:0004325) | Decreased body weight | Frequent [Orphanet] | 492 / 7739 | |||
|
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(HPO:0001006) | Hypotrichosis | Frequent [Orphanet] | 219 / 7739 | |||
|
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(HPO:0008065) | Aplasia/Hypoplasia of the skin | Occasional [Orphanet] | 81 / 7739 | |||
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(HPO:0000958) | Dry skin | Frequent [Orphanet] | 152 / 7739 | |||
|
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(HPO:0001597) | Abnormality of the nail | Frequent [Orphanet] | 115 / 7739 | |||
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(HPO:0001029) | Poikiloderma | Frequent [Orphanet] | 23 / 7739 | |||
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(HPO:0100585) | Telangiectasia of the skin | Occasional [Orphanet] | 66 / 7739 | |||
|
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(HPO:0001063) | Acrocyanosis | Frequent [Orphanet] | 56 / 7739 | |||
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(HPO:0000989) | Pruritus | Frequent [Orphanet] | 111 / 7739 | |||
|
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(HPO:0000992) | Cutaneous photosensitivity | Occasional [Orphanet] | 75 / 7739 | |||
|
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(HPO:0010783) | Erythema | Very frequent [Orphanet] | 138 / 7739 | |||
|
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(HPO:0200042) | Skin ulcer | Frequent [Orphanet] | 138 / 7739 | |||
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(HPO:0011675) | Arrhythmia | Occasional [Orphanet] | 226 / 7739 | |||
|
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(HPO:0012089) | Arteritis | Occasional [Orphanet] | 40 / 7739 | |||
|
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(HPO:0001637) | Abnormality of the myocardium | Occasional [Orphanet] | 76 / 7739 | |||
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(HPO:0002092) | Pulmonary hypertension | Occasional [Orphanet] | 109 / 7739 | |||
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(HPO:0001697) | Abnormality of the pericardium | Occasional [Orphanet] | 52 / 7739 | |||
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(HPO:0001677) | Coronary artery disease | Occasional [Orphanet] | 58 / 7739 | |||
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(HPO:0002665) | Lymphoma | Occasional [Orphanet] | 60 / 7739 | |||
|
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(HPO:0001879) | Abnormality of eosinophils | Occasional [Orphanet] | 20 / 7739 | |||
|
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(HPO:0000969) | Edema | Very frequent [Orphanet] | 117 / 7739 | |||
|
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(HPO:0100758) | Gangrene | Occasional [Orphanet] | 25 / 7739 | |||
|
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(HPO:0001945) | Fever | Occasional [Orphanet] | 218 / 7739 | |||
|
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(HPO:0011227) | Elevated C-reactive protein level | Very frequent [Orphanet] | 55 / 7739 | |||
|
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(HPO:0001608) | Abnormality of the voice | Occasional [Orphanet] | 126 / 7739 | |||
|
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(HPO:0002093) | Respiratory insufficiency | Frequent [Orphanet] | 410 / 7739 | |||
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(HPO:0002091) | Restrictive ventilatory defect | Frequent [Orphanet] | 46 / 7739 | |||
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(HPO:0002205) | Recurrent respiratory infections | Frequent [Orphanet] | 254 / 7739 | |||
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(HPO:0002206) | Pulmonary fibrosis | Frequent [Orphanet] | 51 / 7739 | |||
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(HPO:0100526) | Neoplasm of the lung | Occasional [Orphanet] | 26 / 7739 | |||
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(HPO:0002664) | Neoplasm | Occasional [Orphanet] | 111 / 7739 | |||
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(HPO:0002960) | Autoimmunity | Very frequent [Orphanet] | 78 / 7739 | |||
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(HPO:0003457) | EMG abnormality | Very frequent [Orphanet] | 78 / 7739 | |||
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(HPO:0001252) | Muscular hypotonia | Very frequent [Orphanet] | 990 / 7739 | |||
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(HPO:0001324) | Muscle weakness | Very frequent [Orphanet] | 859 / 7739 | |||
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(HPO:0003326) | Myalgia | Very frequent [Orphanet] | 143 / 7739 | |||
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(HPO:0003549) | Abnormality of connective tissue | Occasional [Orphanet] | 22 / 7739 | |||
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([DEL]MedDRA:10011224) | Cough | Frequent [Orphanet] | 70 / 7739 | |||
|
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(HPO:0030350) | Erythematous papule | Frequent [Orphanet] | 123 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
|---|