Narcolepsy-cataplexy

General Information (adopted from Orphanet):

Synonyms, Signs: Gélineau disease
Number of Symptoms 18
OrphanetNr: 2073
OMIM Id: 161400
605841
609039
612417
612851
614223
614250
ICD-10: G47.4
UMLs: C0027404
C0751362
MeSH: D009290
MedDRA: 10028713
Snomed: 193042000
60380001

Prevalence, inheritance and age of onset:

Prevalence: 25 of 100 000 [Orphanet]
Inheritance: Unknown
[Orphanet]
Age of onset: Childhood
Adolescent
Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Sleep disorder
 -Rare neurologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0000496) Abnormality of eye movement Frequent [Orphanet] 79 / 7739
2
 (HPO:0000478) Abnormality of the eye Frequent [Orphanet] 126 / 7739
3
 (HPO:0000738) Hallucinations Very frequent [Orphanet] 60 / 7739
4
 (HPO:0002494) Abnormal rapid eye movement sleep 4 / 7739
5
 (HPO:0002189) Excessive daytime sleepiness 8 / 7739
6
 (HPO:0002360) Sleep disturbance Very frequent [Orphanet] 113 / 7739
7
 (HPO:0002524) Cataplexy 8 / 7739
8
 (HPO:0002330) Paroxysmal drowsiness 2 / 7739
9
 (HPO:0002167) Neurological speech impairment Occasional [Orphanet] 308 / 7739
10
 (HPO:0006896) Hypnopompic hallucinations 2 / 7739
11
 (HPO:0002354) Memory impairment Very frequent [Orphanet] 63 / 7739
12
 (HPO:0002519) Hypnagogic hallucinations 3 / 7739
13
 (HPO:0001513) Obesity Occasional [Orphanet] 172 / 7739
14
 (HPO:0001695) Cardiac arrest Occasional [Orphanet] 87 / 7739
15
 (HPO:0001324) Muscle weakness Very frequent [Orphanet] 859 / 7739
16
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739
17
 (HPO:0001425) Heterogeneous 132 / 7739
18
 (HPO:0030050) Narcolepsy 6 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: