Pai syndrome

General Information (adopted from Orphanet):

Synonyms, Signs: PAI SYNDROME
Median cleft of the upper lip - corpus callosum lipoma - cutaneous polyps
Number of Symptoms 25
OrphanetNr: 1993
OMIM Id: 155145
ICD-10: Q87.8
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: 37 cases [Orphanet]
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset: Neonatal
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Frontonasal dysplasia
 -Rare bone disease
 -Rare developmental defect during embryogenesis
Orofacial clefting syndrome
 -Rare developmental defect during embryogenesis
 -Rare genetic disease
 -Rare maxillo-facial surgical disease
 -Rare otorhinolaryngologic disease

Symptom Information: Sort by abundance 

1
(HPO:0000316) Hypertelorism Frequent [Orphanet] 644 / 7739
2
(HPO:0000163) Abnormality of the oral cavity Frequent [Orphanet] 37 / 7739
3
(HPO:0000337) Broad forehead 116 / 7739
4
(HPO:0000506) Telecanthus Frequent [Orphanet] 156 / 7739
5
(HPO:0100582) Nasal polyposis Very frequent [Orphanet] 14 / 7739
6
(HPO:0010285) Oral synechia Frequent [Orphanet] 31 / 7739
7
(HPO:0005280) Depressed nasal bridge Very frequent [Orphanet] 381 / 7739
8
(HPO:0002084) Encephalocele Occasional [Orphanet] 70 / 7739
9
(HPO:0000193) Bifid uvula 66 / 7739
10
(HPO:0000161) Median cleft lip Very frequent [Orphanet] 27 / 7739
11
(HPO:0000366) Abnormality of the nose Occasional [Orphanet] 56 / 7739
12
(HPO:0000494) Downslanted palpebral fissures Occasional [Orphanet] 328 / 7739
13
(HPO:0000218) High palate 356 / 7739
14
(HPO:0000174) Abnormality of the palate Very frequent [Orphanet] 298 / 7739
15
(HPO:0000612) Iris coloboma Occasional [Orphanet] 116 / 7739
16
(HPO:0006866) Midline central nervous system lipomas 1 / 7739
17
(HPO:0100835) Benign neoplasm of the central nervous system Very frequent [Orphanet] 12 / 7739
18
(HPO:0010609) Skin tags Very frequent [Orphanet] 12 / 7739
19
(HPO:0001031) Subcutaneous lipoma Very frequent [Orphanet] 112 / 7739
20
(HPO:0007370) Aplasia/Hypoplasia of the corpus callosum Occasional [Orphanet] 180 / 7739
21
(OMIM) Nasal mucosal polyps 1 / 7739
22
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
23
(OMIM) Skin tags containing cartilage on forehead 1 / 7739
24
(OMIM) Facial skin polyps 1 / 7739
25
(OMIM) Median cleft upper lip 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Pai syndrome is characterized by mild hypertelorism, midline cleft lip, nasal and facial polyps, pericallosal lipoma, ocular anomalies, and normal neuropsychologic development (Guion-Almeida et al., 2007).
Clinical Description OMIM Pai syndrome is a rare disorder combining median cleft upper lip and polyps of the facial skin and nasal mucosa (Sharma, 1974; Ponniah, 1977; Nakamura et al., 1985; Pai et al., 1987). In addition, midline lipomas of the ...