Gollop-Wolfgang complex

General Information (adopted from Orphanet):

Synonyms, Signs: GOLLOP-WOLFGANG COMPLEX
GWC
Bifid femur - monodactylous ectrodactyly
Number of Symptoms 15
OrphanetNr: 1986
OMIM Id: 228250
ICD-10: Q74.8
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: 200 cases [Orphanet]
Inheritance: Autosomal dominant
Autosomal recessive
[Orphanet]
Age of onset: Neonatal
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Dysostosis with combined reduction defects of upper and lower limbs
 -Rare bone disease
 -Rare developmental defect during embryogenesis
Syndrome with limb duplication, polydactyly, syndactyly, and/or hyperphalangy
 -Rare bone disease
 -Rare developmental defect during embryogenesis
Syndrome with limb reduction defects
 -Rare bone disease
 -Rare developmental defect during embryogenesis

Symptom Information: Sort by abundance 

1
(HPO:0010443) Bifid femur 2 / 7739
2
(HPO:0002997) Abnormality of the ulna Frequent [Orphanet] 75 / 7739
3
(HPO:0004058) Hand monodactyly 8 / 7739
4
(HPO:0009380) Aplasia of the fingers Very frequent [Orphanet] 51 / 7739
5
(HPO:0200054) Foot monodactyly 6 / 7739
6
(HPO:0002823) Abnormality of the femur Very frequent [Orphanet] 61 / 7739
7
(HPO:0001171) Split hand 72 / 7739
8
(HPO:0009556) Absent tibia 9 / 7739
9
(HPO:0003982) Absent ulna 7 / 7739
10
(HPO:0002992) Abnormality of the tibia Very frequent [Orphanet] 51 / 7739
11
(OMIM) Bifurcated femur 1 / 7739
12
(OMIM) Monodactyly of feet 1 / 7739
13
(HPO:0000007) Autosomal recessive inheritance 2538 / 7739
14
(OMIM) Ectrodactyly of hand 2 / 7739
15
(OMIM) Monodactyly of hand 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Gollop et al. (1980) described 2 brothers, each with 1 normal upper limb; 1 had tridactylous ectrodactyly of 1 hand with normal radius and ulna, and the other had monodactyly of 1 hand with absent ulna. Both had ...