White sponge nevus
General Information (adopted from Orphanet):
Synonyms, Signs: |
LEUKOKERATOSIS, HEREDITARY MUCOSAL WSN white sponge nevus of cannon Hereditary mucosal leukokeratosis |
Number of Symptoms | 7 |
OrphanetNr: | 171723 |
OMIM Id: |
193900
|
ICD-10: |
Q38.6 |
UMLs: |
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MeSH: |
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MedDRA: |
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Snomed: |
389203001 |
Prevalence, inheritance and age of onset:
Prevalence: | No data available. |
Inheritance: |
Autosomal dominant [Orphanet] |
Age of onset: |
|
Disease classification (adopted from Orphanet):
Parent Diseases: |
Genetic skin tumor
-Rare genetic disease Rare nevus -Rare oncologic disease -Rare skin disease |
Symptom Information:
|
(HPO:0002745) | Oral leukoplakia | 17 / 7739 | ||||
|
(HPO:0001939) | Abnormality of metabolism/homeostasis | 328 / 7739 | ||||
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(HPO:0000006) | Autosomal dominant inheritance | 2518 / 7739 | ||||
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(OMIM) | Thickened white opalescent spongy-fold mucosa in mouth | 1 / 7739 | ||||
|
(OMIM) | Vaginal, rectal and nasal leukokeratosis | 1 / 7739 | ||||
|
(OMIM) | Characteristic cell-within-cell histologic change | 1 / 7739 | ||||
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(OMIM) | No conjunctival involvement | 1 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
Description: (OMIM) |
White sponge nevus is a rare autosomal dominant disorder of noncornifying squamous epithelial differentiation that presents clinically as white, soft, thick plaques of the oral mucosa. Less frequently, the mucous membranes of the nose, esophagus, genitalia, and rectum ... |
Clinical Description OMIM |
White sponge nevus is manifested by thickened spongy-fold mucosa with a white opalescent tint in the mouth. The vagina, rectum, and nasal cavity may be similarly involved. It is differentiated from benign intraepithelial dyskeratosis (127600) by the presence ... |
Molecular genetics OMIM |
In affected members of 2 Scottish kindreds with white sponge nevus, Rugg et al. (1995, 1995) found heterozygosity for a 3-bp deletion in the 1A domain of the KRT4 gene (123940.0001). In 3 affected members of ... |