Heart-hand syndrome, Slovenian type
General Information (adopted from Orphanet):
Synonyms, Signs: |
Atrio-digital dysplasia, Slovenian type Cardiac conduction disease-dilated cardiomyopathy-brachydactyly |
Number of Symptoms | 14 |
OrphanetNr: | 168796 |
OMIM Id: |
610140
|
ICD-10: |
Q87.2 |
UMLs: |
C1857829 |
MeSH: |
C535852 |
MedDRA: |
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Snomed: |
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Prevalence, inheritance and age of onset:
Prevalence: | < 1 of 100 000 |
Inheritance: |
Autosomal dominant 18611980 [IBIS] |
Age of onset: |
Adult 15996213 [IBIS] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Genetic cardiac rhythm disease
-Rare cardiac disease -Rare genetic disease Heart-hand syndrome -Rare bone disease -Rare developmental defect during embryogenesis Syndrome associated with dilated cardiomyopathy -Rare cardiac disease -Rare genetic disease |
Symptom Information:
|
(HPO:0001159) | Syndactyly | 15996213 | IBIS | 140 / 7739 | ||
|
(HPO:0010239) | Aplasia of the middle phalanx of the hand | 15996213 | IBIS | 3 / 7739 | ||
|
(HPO:0001204) | Distal symphalangism of hands | 15996213 | IBIS | 13 / 7739 | ||
|
(HPO:0001156) | Brachydactyly syndrome | Occasional [IBIS] | 10% (n=10) | 15996213 | IBIS | 180 / 7739 |
|
(HPO:0001644) | Dilated cardiomyopathy | 15996213 | IBIS | 141 / 7739 | ||
|
(HPO:0003198) | Myopathy | rare [HPO:skoehler] | 18611980 | IBIS | 151 / 7739 | |
|
(OMIM) | Proximal weakness, upper extremities (1 patient) | 15996213 | IBIS | 1 / 7739 | ||
|
(HPO:0001699) | Sudden death | Frequent [IBIS] | 33% (n=10) | 15996213 | IBIS | 34 / 7739 |
|
(OMIM) | Duplication of bases of second metatarsals | 15996213 | IBIS | 1 / 7739 | ||
|
(HPO:0030084) | Clinodactyly | 15996213 | IBIS | 90 / 7739 | ||
|
(OMIM) | Extra ossicles | 15996213 | IBIS | 1 / 7739 | ||
|
(OMIM) | Conduction disease, sinoatrial and atrioventricular, progressive | 15996213 | IBIS | 1 / 7739 | ||
|
(MedDRA:10065341) | Ventricular tachyarrhythmia | 15996213 | IBIS | 2 / 7739 | ||
|
(OMIM) | Short or absent middle phalanges | 15996213 | IBIS | 1 / 7739 |
Associated genes:
LMNA |
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
---|---|---|---|
LMNA | rs267607582 | pathogenic | RCV000015618.26 |
Additional Information:
Clinical Description OMIM |
Sinkovec et al. (2005) reported a Slovenian family with 10 affected members in 4 generations who had adult-onset progressive sinoatrial and atrioventricular conduction disease, sudden death due to ventricular tachyarrhythmia, dilated cardiomyopathy, and a unique type of brachydactyly ... |
Molecular genetics OMIM |
Renou et al. (2008) analyzed the LMNA gene in 12 members of the family with heart-hand syndrome originally reported by Sinkovec et al. (2005) and identified a heterozygous splice site mutation (150330.0045) that cosegregated with disease in 6 ... |