MULTIPLE FIBROADENOMAS OF THE BREAST

General Information (adopted from Orphanet):

Synonyms, Signs: MFAB
Number of Symptoms 2
OrphanetNr:
OMIM Id: 615554
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
2
(OMIM) More than 3 fibroadenomas in a single breast 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Fibroadenoma represents a benign breast disease characterized by lobuloalveolar growth with abnormally high proliferation of the epithelium. Patients with more than 3 fibroadenomas in 1 breast are considered to have multiple fibroadenomas (summary by Bogorad et al., 2008). ...
Molecular genetics OMIM In 74 Caucasian women with multiple fibroadenomas of the breast, who were negative for mutation in the prolactin gene (PRL; 176760), Bogorad et al. (2008) analyzed the PRLR gene and identified a missense mutation (I146L; 176761.0001) in 4 ...