Cis-3-hexen-1-ol (C3HEX) is present in a wide range of foods and beverages, including wine and spirits, olive oil, vegetables, fruit, and green tea. C3HEX is commonly associated with sensory characteristics such as 'green' and 'grassy.' The probability of ... Cis-3-hexen-1-ol (C3HEX) is present in a wide range of foods and beverages, including wine and spirits, olive oil, vegetables, fruit, and green tea. C3HEX is commonly associated with sensory characteristics such as 'green' and 'grassy.' The probability of an individual's ability to detect C3HEX at a particular intensity (the R-index) can be estimated, and the threshold for detection is normally distributed (summary by Jaeger et al., 2010).
In a sample of 52 unrelated volunteers, including 48 who were previously studied by Jaeger et al. (2010), McRae et al. (2012) analyzed 25 odorant receptor genes on chromosome 6p22 and tested for association between variation in the ... In a sample of 52 unrelated volunteers, including 48 who were previously studied by Jaeger et al. (2010), McRae et al. (2012) analyzed 25 odorant receptor genes on chromosome 6p22 and tested for association between variation in the coding regions as well as 136 SNPs from the previous study and the threshold concentrations for ability to detect C3HEX. They identified a SNP within the coding region of the OR2J3 gene, dbSNP rs28757581 (T113A; 615016.0001), that was strongly associated with threshold concentrations for C3HEX and was found to lower sensitivity to the compound. The T113A variant was in linkage disequilibrium with another OR2J3 variant, dbSNP rs3749977 (R226Q; 615016.0002), which also compromised the ability to detect C3HEX; together, the 2 variants abolished the ability of OR2J3 to respond to C3HEX in cell assays. The T113A/R226Q haplotype explained 26.4% of variance in detection thresholds to C3HEX in vivo.