PERIODIC FEVER, MENSTRUAL CYCLE-DEPENDENT

General Information (adopted from Orphanet):

Synonyms, Signs:
Number of Symptoms 16
OrphanetNr:
OMIM Id: 614674
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0002076) Migraine 41 / 7739
2
(HPO:0000819) Diabetes mellitus 131 / 7739
3
(HPO:0200067) Recurrent spontaneous abortion rare [HPO:skoehler] 6 / 7739
4
(HPO:0001945) Fever 218 / 7739
5
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
6
(OMIM) Tremor with febrile episodes (rare) 1 / 7739
7
(OMIM) High fever (38-41 degrees centigrade), recurrent with each menstrual cycle 1 / 7739
8
(OMIM) TNF continuously elevated (in some patients) 1 / 7739
9
(OMIM) IL6 continuously elevated (in some patients) 1 / 7739
10
(OMIM) Fetal loss after 6 to 7 weeks of gestation (in some patients) 1 / 7739
11
(OMIM) Hypercortisolism, mild (in some patients) 1 / 7739
12
(OMIM) Myalgia with febrile episodes (rare) 1 / 7739
13
(OMIM) Periodic fever, luteal phase-dependent (in some patients) 1 / 7739
14
(OMIM) Ataxia with febrile episodes (rare) 1 / 7739
15
(OMIM) Lower extremity weakness with febrile episodes (rare) 1 / 7739
16
(OMIM) Periodic fever, pre- and postovulation (in some patients) 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body ...
Clinical Description OMIM Rutanen et al. (1993) reported 2 Finnish women who had recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle, who also had continuously elevated serum levels of TNF (191160) and IL6 ...
Molecular genetics OMIM In a 33-year-old Taiwanese woman with recurrent fevers associated with her menstrual cycle that were successfully treated with a serotonin receptor antagonist, Jiang et al. (2012) sequenced the serotonin receptor gene HTR1A (109760) and identified a 1-bp deletion ...