Cui et al. (2012) identified 2 missense mutations in the CORIN gene in women with preeclampsia. One, a lys317-to-glu substitution in low density lipoprotein receptor repeat-2 (605236.0001), was found in 1 woman; the other, a ser472-to- gly substitution ... Cui et al. (2012) identified 2 missense mutations in the CORIN gene in women with preeclampsia. One, a lys317-to-glu substitution in low density lipoprotein receptor repeat-2 (605236.0001), was found in 1 woman; the other, a ser472-to- gly substitution in the frizzled-2 domain (605236.0002), was found in 2 women. Neither mutation affected CORIN expression in HEK293 cells, but both markedly reduced CORIN activity in processing pro-atrial natriuretic peptide (ANP; 108780).