Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are ... Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of susceptibility to myopia, see 160700.
Ma et al. (2010) studied 11 affected individuals from a 4-generation Chinese family from Zhejiang province segregating autosomal dominant high myopia. The average age at diagnosis of myopia was 6.9 years (range, 4 to 11 years). The average ... Ma et al. (2010) studied 11 affected individuals from a 4-generation Chinese family from Zhejiang province segregating autosomal dominant high myopia. The average age at diagnosis of myopia was 6.9 years (range, 4 to 11 years). The average spherical component refractive error for the affected individuals was -11.59 +/- 5.26 diopters (D) (range, -6.5 to -26 D). Mean axial length in highly myopic individuals was 29.17 +/- 1.50 mm (range, 26.80 to 31.42 mm) compared to 23.59 +/- 1.04 mm (range, 22.03 to 25.72 mm) in non-highly myopic family members. Ophthalmologic examination excluded known ocular diseases associated with myopia, including keratoconus (see 148300), spherophakia, ectopia lentis (see 129600), retinal dystrophy (see 268000), and optic atrophy (see 165500). Males and females were equally affected.
In a 4-generation Chinese family segregating autosomal dominant high myopia mapping to chromosome 5p15.1-p13.3, Ma et al. (2010) analyzed 6 candidate genes, including CDH6 (603007), CDH10 (604555), CDH12 (600562), PDZD2 (610697), and GOLPH3 (612207), but did not identify ... In a 4-generation Chinese family segregating autosomal dominant high myopia mapping to chromosome 5p15.1-p13.3, Ma et al. (2010) analyzed 6 candidate genes, including CDH6 (603007), CDH10 (604555), CDH12 (600562), PDZD2 (610697), and GOLPH3 (612207), but did not identify any disease-causing mutation.