In a study of 95 healthy Asian Indian men, Petersen et al. (2010) found that carriers of variant alleles in the APOC3 gene (107720) on 11q23, -455T-C (dbSNP rs2854116) and/or -482C-T (dbSNP rs2854117), which are in strong linkage ... In a study of 95 healthy Asian Indian men, Petersen et al. (2010) found that carriers of variant alleles in the APOC3 gene (107720) on 11q23, -455T-C (dbSNP rs2854116) and/or -482C-T (dbSNP rs2854117), which are in strong linkage disequilibrium, had a 30% increase in fasting plasma APOC3 and a 60% increase in fasting plasma triglycerides compared to individuals who were homozygous for the wildtype alleles. Carriers of the variant alleles also had a 2-fold increase in plasma triglyceride and retinyl fatty acid ester concentrations after an oral fat-tolerance test, as well as a 46% reduction in plasma triglyceride clearance. The prevalence of nonalcoholic fatty liver disease was 38% among carriers of the variant alleles compared to 0% among wildtype homozygotes, and those with NAFLD had marked insulin resistance. The findings were confirmed in a validation study involving 163 non-Asian Indian men.