Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and ... Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and often have overlapping psychologic disorders, such as Tourette syndrome (GTS; 137580) or obsessive-compulsive disorder (OCD; 164230) (review by Novak et al., 2009).
Kerbeshian and Burd (1991) reported a 37-year-old woman with trichotillomania manifest as chronic pulling out of her eyebrows and eyelashes. She reported compulsive behavior, such as avoiding sidewalk cracks and counting the number of drips from a faucet, ... Kerbeshian and Burd (1991) reported a 37-year-old woman with trichotillomania manifest as chronic pulling out of her eyebrows and eyelashes. She reported compulsive behavior, such as avoiding sidewalk cracks and counting the number of drips from a faucet, from age 6 years. She had experienced repeated sexual and physical abuse throughout her life. The episodes of trichotillomania were described as an irresistible impulse followed by a sense of tension release. She also had depression (608516). Treatment with clomipramine resulted in symptom improvement. Her sister and brother also had trichotillomania, but detailed history was not available.
Abelson et al. (2005) identified a 1-bp deletion in the SLITRK1 gene (609678.0001) in a boy with Tourette syndrome and ADHD (143465). The mother, who had severe trichotillomania, also had the mutation, which was not found in 3,600 ... Abelson et al. (2005) identified a 1-bp deletion in the SLITRK1 gene (609678.0001) in a boy with Tourette syndrome and ADHD (143465). The mother, who had severe trichotillomania, also had the mutation, which was not found in 3,600 control chromosomes.