TRICHOTILLOMANIA

General Information (adopted from Orphanet):

Synonyms, Signs: TTM
Number of Symptoms 8
OrphanetNr:
OMIM Id: 613229
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
Multifactorial
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000722) Obsessive-compulsive behavior 35 / 7739
2
(HPO:0012167) Hair-pulling 1 / 7739
3
(HPO:0001596) Alopecia 162 / 7739
4
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
5
(HPO:0001426) Multifactorial inheritance 37 / 7739
6
(OMIM) Distress and functional impairment resulting from hair pulling behavior 1 / 7739
7
(OMIM) Hair pulling, chronic, compulsive, repetitive 1 / 7739
8
(OMIM) Alopecia resulting from compulsive hair pulling 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Trichotillomania (TTM) is a neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. The activity causes distress to the individual and often interferes with functioning. Affected individuals may develop physical complications and ...
Clinical Description OMIM Kerbeshian and Burd (1991) reported a 37-year-old woman with trichotillomania manifest as chronic pulling out of her eyebrows and eyelashes. She reported compulsive behavior, such as avoiding sidewalk cracks and counting the number of drips from a faucet, ...
Molecular genetics OMIM Abelson et al. (2005) identified a 1-bp deletion in the SLITRK1 gene (609678.0001) in a boy with Tourette syndrome and ADHD (143465). The mother, who had severe trichotillomania, also had the mutation, which was not found in 3,600 ...