SHORT SLEEPER

General Information (adopted from Orphanet):

Synonyms, Signs: SHORT SLEEP PHENOTYPE
Number of Symptoms 6
OrphanetNr:
OMIM Id: 612975
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(OMIM) Normal sleep-onset time (normal time of falling asleep) 1 / 7739
2
(OMIM) Increased activity period 1 / 7739
3
(OMIM) Shorter daily total sleep times compared to age-matched controls 1 / 7739
4
(OMIM) Earlier sleep-offset time (earlier awakening) 1 / 7739
5
(OMIM) Individuals require less sleep in a 24-hour period compared to age-matched controls 1 / 7739
6
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) In a review of various classification schemes for sleep disorders, Thorpy (1990) listed 'short sleeper' under the broad category of 'disorders of initiating and maintaining sleep' (DIMS); however, the short sleeper phenotype or trait is not considered a ...
Clinical Description OMIM He et al. (2009) reported a mother and daughter with lifelong shorter daily sleep times than control individuals. The self-reported non-workday habitual sleep-offset times (awakening times) were much earlier than those of controls, although sleep-onset times (time of ...
Molecular genetics OMIM In a mother and daughter with the short sleep phenotype, He et al. (2009) identified a heterozygous mutation in the DEC2 gene (P385R; 606200.0001).