Enzinger (1979) first described 'angiomatoid' fibrous histiocytoma as a distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. It tends to recur after surgical excision. Characteristic microscopic ... Enzinger (1979) first described 'angiomatoid' fibrous histiocytoma as a distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. It tends to recur after surgical excision. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. When the classic cyst-like spaces, peripheral fibrosis, and chronic inflammatory infiltrate are not seen, the lesions may be misdiagnosed as cellular or sclerosing hemangiomas, hemangiopericytoma, hemangioendothelioma, and others (Waters et al., 2000; Antonescu et al., 2007).