Nabbout et al. (2007) reported a 4-generation French family in which 13 individuals had febrile seizures. Age at onset ranged from 6 months to 3 years, and resolved by age 5 years in all but 1 patient, who ... Nabbout et al. (2007) reported a 4-generation French family in which 13 individuals had febrile seizures. Age at onset ranged from 6 months to 3 years, and resolved by age 5 years in all but 1 patient, who had his last seizure by age 7. Five of these patients subsequently developed childhood absence epilepsy (CAE) at age 2.5 to 4 years. The CAE seizures were characterized by isolated disruption of consciousness without other symptoms, although 1 patient showed rare automatisms. EEG in 3 patients with CAE showed characteristic 3-Hz spike-wave discharges. CAE seizures remitted by puberty in all but 1 patient. A sixth patient with febrile seizures, who had a long-lasting episode followed by hemiparesis, later developed treatment-resistant temporal lobe epilepsy associated with hippocampal sclerosis. All affected family members had normal neurologic development.