Brownstein et al. (2006) examined 12 affected and 12 unaffected members of a 5-generation Israeli family with otosclerosis. All of the otosclerotic members of the family experienced progressive hearing loss, beginning late in the third decade to the ... Brownstein et al. (2006) examined 12 affected and 12 unaffected members of a 5-generation Israeli family with otosclerosis. All of the otosclerotic members of the family experienced progressive hearing loss, beginning late in the third decade to the fifth decade; the female members of the family reported first noticing hearing loss about a decade sooner than the males. There was large variability between affected individuals in age at onset, type of hearing loss, shape of audiogram, and symmetry of hearing loss. Eight patients had bilateral and 3 patients had unilateral conductive or mixed hearing loss, and 1 patient had sensorineural hearing loss. There were no reports of tinnitus.