Wang et al. (2004) reported a large 5-generation Filipino kindred segregating juvenile-onset primary open angle glaucoma (JOAG) in an autosomal dominant fashion. Clinical characteristics were determined for 95 family members, 22 of whom were diagnosed with JOAG, including ... Wang et al. (2004) reported a large 5-generation Filipino kindred segregating juvenile-onset primary open angle glaucoma (JOAG) in an autosomal dominant fashion. Clinical characteristics were determined for 95 family members, 22 of whom were diagnosed with JOAG, including 11 males. Affected individuals were typically diagnosed before 35 years of age and had grade III-IV gonioscopy of the anterior chamber, intraocular pressures greater than or equal to 22 mm Hg, and chacteristic optic disc and visual field changes.
In a screen of the WDR36 gene (609669), which is located centromeric to the GLC1M interval at 5q22.1, Pang et al. (2006) found no mutations within any of the 23 coding exons or splicing junctions. Fan et al. ... In a screen of the WDR36 gene (609669), which is located centromeric to the GLC1M interval at 5q22.1, Pang et al. (2006) found no mutations within any of the 23 coding exons or splicing junctions. Fan et al. (2007) excluded NRG2 as the causative gene for GLC1M.