Eosinophilic esophagitis (EOE) has an incidence of approximately 1 per 10,000 people. Symptoms include difficulty feeding, failure to thrive, vomiting, epigastric or chest pain, dysphagia, and food impaction. Individuals with EOE are predominantly young males with a high ... Eosinophilic esophagitis (EOE) has an incidence of approximately 1 per 10,000 people. Symptoms include difficulty feeding, failure to thrive, vomiting, epigastric or chest pain, dysphagia, and food impaction. Individuals with EOE are predominantly young males with a high rate of atopic disease, and the diagnosis is made by endoscopy and biopsy findings of isolated eosinophils in the esophagus (summary by Rothenberg et al., 2010). - Genetic Heterogeneity of Eosinophilic Esophagitis Eosinophilic esophagitis-1 (EOE1) is associated with variation at chromosome 7q11.2. Another locus (EOE2; 613412) has been been associated with variation in the TSLP gene (607003) on chromosome 5q22.
Eosinophilic esophagitis (EOE) is defined histologically by the presence of proliferative changes, including thickening of the basal epithelial layer and elongation of papillae, a minimum of 24 eosinophils per high-power field in the distal esophagus, and the absence ... Eosinophilic esophagitis (EOE) is defined histologically by the presence of proliferative changes, including thickening of the basal epithelial layer and elongation of papillae, a minimum of 24 eosinophils per high-power field in the distal esophagus, and the absence of eosinophilia in any other intestinal segment. The disease is differentiated from reflux esophagitis (109350) on the basis of the magnitude of mucosal eosinophilia and lack of response to acid suppression (Noel et al., 2004). In a population-based demographic study of pediatric eosinophilic esophagitis, Noel et al. (2004) identified 315 cases that met the diagnostic criteria. Further study of 103 of those patients revealed that 70% had coexisting eosinophilic involvement in the proximal esophagus; 71% were male, with a mean age of 10.5 years. Demographic analysis showed a strong familial pattern, including 3 sib pairs; and the mother of 1 of the sib pairs was also diagnosed with eosinophilic esophagitis.