ASPERGER SYNDROME, SUSCEPTIBILITY TO, 1

General Information (adopted from Orphanet):

Synonyms, Signs: ASPG1
Number of Symptoms 15
OrphanetNr:
OMIM Id: 608638
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Multifactorial
Sporadic
[Omim]
Age of onset: Juvenile onset
[Omim]

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000733) Stereotypy 58 / 7739
2
(HPO:0000735) Impaired social interactions 20 / 7739
3
(HPO:0000728) Impaired ability to form peer relationships 8 / 7739
4
(HPO:0000721) Lack of spontaneous play 11 / 7739
5
(HPO:0000753) Autism with high cognitive abilities 1 / 7739
6
(HPO:0000732) Inflexible adherence to routines or rituals 11 / 7739
7
(HPO:0000723) Restrictive behavior 11 / 7739
8
(HPO:0000758) Impaired use of nonverbal behaviors 11 / 7739
9
(HPO:0001426) Multifactorial inheritance 37 / 7739
10
(HPO:0003745) Sporadic 131 / 7739
11
(HPO:0003621) Juvenile onset 105 / 7739
12
(OMIM) Relatively higher cognitive abilities than classic autism 4 / 7739
13
(OMIM) Stereotyped, repetitive behavior 11 / 7739
14
(OMIM) Impaired use of nonverbal behaviors, such as eye-to-eye gaze, facial expression, body posture, and gestures 11 / 7739
15
(OMIM) Normal, timely language development 4 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Asperger syndrome is considered to be a form of childhood autism (see, e.g., 209850). The DSM-IV (American Psychiatric Association, 1994) specifies several diagnostic criteria for Asperger syndrome, which has many of the same features as autism. In general, ...
Clinical Description OMIM Asperger (1944) described a syndrome, which he termed 'autistic psychopathy,' in which persons of apparently normal intelligence exhibited an impairment in social interaction and behavioral abnormalities without delays in language development.
Population genetics OMIM Bertrand et al. (2001) performed a prevalence study of autism spectrum disorders in Brick Township, New Jersey. There were 6.7 cases per 1,000 children, aged 3 to 10 years, in 1998. The prevalence for children whose condition met ...