CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1

General Information (adopted from Orphanet):

Synonyms, Signs: CORONARY ARTERY DISEASE WITH MYOCARDIAL INFARCTION
ADCAD1
Number of Symptoms 14
OrphanetNr:
OMIM Id: 608320
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0001677) Coronary artery disease 58 / 7739
2
(HPO:0001658) Myocardial infarction 30 / 7739
3
(HPO:0000822) Hypertension 224 / 7739
4
(HPO:0003124) Hypercholesterolemia 53 / 7739
5
(OMIM) No congenital heart defect 1 / 7739
6
(OMIM) EKG pattern consistent with acute MI 1 / 7739
7
(OMIM) Coronary angiogram showing greater than 70% stenosis 1 / 7739
8
(OMIM) No insulin-dependent diabetes mellitus 1 / 7739
9
(MedDRA:10007548) Cardiac enzymes increased 4 / 7739
10
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
11
(OMIM) History of coronary artery bypass surgery (CABG) 1 / 7739
12
(OMIM) Chest pain greater than 30 minutes duration 1 / 7739
13
(OMIM) History of percutaneous coronary angioplasty (PTCA) 1 / 7739
14
(OMIM) No childhood hypertension 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Coronary artery disease (CAD) and its most important complication, acute myocardial infarction (MI), are leading causes of death and disability in the developed world. Multiple risk factors for CAD/MI have been identified, including family history, hypertension, hypercholesterolemia, obesity, ...
Molecular genetics OMIM In all affected members of the large family with autosomal dominant CAD studied by them, Wang et al. (2003) found a 21-bp deletion in exon 11 of the MEF2A gene (600660.0001). The deleted 7 amino acids are conserved ...