NASOPHARYNGEAL CARCINOMA
General Information (adopted from Orphanet):
| Synonyms, Signs: |
NASOPHARYNGEAL CANCER NASOPHARYNGEAL CARCINOMA, SUSCEPTIBILITY TO, 1, INCLUDED NPCA1, INCLUDED NPCA NPC |
| Number of Symptoms | 2 |
| OrphanetNr: | |
| OMIM Id: |
607107
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| ICD-10: |
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| UMLs: |
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| MeSH: |
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| MedDRA: |
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| Snomed: |
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Prevalence, inheritance and age of onset:
| Prevalence: | No data available. |
| Inheritance: |
Polygenic inheritance [Omim] |
| Age of onset: |
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Disease classification (adopted from Orphanet):
| Parent Diseases: | No data available. |
Symptom Information:
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(HPO:0100630) | Neoplasia of the nasopharynx | 2 / 7739 | ||||
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(HPO:0010982) | Polygenic inheritance | 14 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
| Description: (OMIM) |
Nasopharyngeal carcinoma (NPC, NPCA) is a multifactorial malignancy associated with both genetic and environmental factors. The cancer arises from the epithelium of the nasopharynx. The Epstein-Barr virus has been implicated (Tse et al., 2009). A susceptibility ... |
| Molecular genetics OMIM |
- Somatic Mutations Sun et al. (1992) identified a somatic mutation in the p53 gene (R280T; 191170.0024) in tumor tissue from a Chinese patient with nasopharyngeal carcinoma. Chakrani et al. (1995) studied 41 primary tumors of ... |
| Population genetics OMIM | Nasopharyngeal carcinoma is most prominent in southeast Asia regions, including China, Hong Kong, and Taiwan, where the annual incidence rate is approximately 25-fold higher than in the Western world (Tse et al., 2009). |