DERMATITIS, ATOPIC

General Information (adopted from Orphanet):

Synonyms, Signs: ECZEMA, ATOPIC DERMATITIS, ATOPIC, 1, INCLUDED
ATOD1, INCLUDED
ATOD
Number of Symptoms 32
OrphanetNr:
OMIM Id: 603165
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0003193) Allergic rhinitis 6 / 7739
2
(HPO:0000563) Keratoconus 25 / 7739
3
(HPO:0000518) Cataract 454 / 7739
4
(HPO:0010697) Anterior pyramidal cataract 22 / 7739
5
(HPO:0000509) Conjunctivitis 47 / 7739
6
(HPO:0000980) Pallor 52 / 7739
7
(HPO:0011123) Inflammatory abnormality of the skin 10 / 7739
8
(HPO:0000989) Pruritus 111 / 7739
9
(HPO:0000976) Eczematoid dermatitis 22 / 7739
10
(HPO:0001047) Atopic dermatitis 20 / 7739
11
(HPO:0000958) Dry skin 152 / 7739
12
(HPO:0001051) Seborrheic dermatitis 25 / 7739
13
(HPO:0001041) Facial erythema 8 / 7739
14
(HPO:0007453) Flexural lichenification 1 / 7739
15
(HPO:0008064) Ichthyosis 108 / 7739
16
(HPO:0001581) Recurrent skin infections 9 / 7739
17
(HPO:0000964) Eczema 81 / 7739
18
(HPO:0012537) Food intolerance 2 / 7739
19
(HPO:0002099) Asthma 62 / 7739
20
(OMIM) Orbital darkening 1 / 7739
21
(OMIM) Infraorbital fold (Dennie-Morgan lines) 1 / 7739
22
(MedDRA:10066295) Keratosis pilaris 11 / 7739
23
(OMIM) Facial or extensor involvement in infants and children (major feature) 1 / 7739
24
(OMIM) White dermatographism 1 / 7739
25
(OMIM) Immediate (type I) skin test reactivity 1 / 7739
26
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
27
(OMIM) Palmar hyperlinearity 1 / 7739
28
(MedDRA:10035111) Pityriasis alba 1 / 7739
29
(MedDRA:10058898) Hand dermatitis 1 / 7739
30
(OMIM) Nipple dermatitis 1 / 7739
31
(OMIM) Elevated IgE 1 / 7739
32
(OMIM) Flexural lichenification in adults (major feature) 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Atopic dermatitis (ATOD), also known as eczema, is a common chronic pruritic inflammatory skin disease with a strong genetic component. Onset typically occurs during the first 2 years of life (review by Soderhall et al., 2007).

...

Clinical Description OMIM Atopic dermatitis commonly begins in infancy or early childhood (Kay et al., 1994; Taylor et al., 1984). Eighty percent of cases of ATOD have elevations of the total serum IgE (147050) concentration. The hallmarks of atopic dermatitis are ...
Molecular genetics OMIM Soderhall et al. (2007) analyzed the ATOD1 candidate gene COL29A1 in 46 unrelated children with atopic dermatitis and 2 controls and identified 13 common and 6 rare sequence variations causing nonsynonymous amino acid substitutions. All coding SNPs were ...
Population genetics OMIM Atopic dermatitis is one of the most common diseases in childhood, affecting 10 to 20% of children in industrialized societies (Beasley and The International Study of Asthma and Allergies in Childhood Steering Committee, 1998).