OSSIFICATION OF THE POSTERIOR LONGITUDINAL LIGAMENT OF SPINE

General Information (adopted from Orphanet):

Synonyms, Signs: OPLL
Number of Symptoms 8
OrphanetNr:
OMIM Id: 602475
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal recessive inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
 (HPO:0001347) Hyperreflexia 363 / 7739
2
 (HPO:0000819) Diabetes mellitus 131 / 7739
3
 (HPO:0011001) Increased bone mineral density 78 / 7739
4
 (HPO:0000925) Abnormality of the vertebral column 20 / 7739
5
 (OMIM) Ectopic ossification of posterior longitudinal spinal ligament (cervical and thoracic spine) 1 / 7739
6
 (HPO:0000007) Autosomal recessive inheritance 2538 / 7739
7
 (HPO:0002176) Spinal cord compression 15 / 7739
8
 (HPO:0002196) Myelopathy 6 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Ossification of the posterior longitudinal ligament of the spine (OPLL) can cause spinal-cord compression (Ono et al., 1977; Tsuyama, 1984). Patients with OPLL frequently present with a severe myelopathy that can lead to tetraparesis. X-ray examination detects OPLL ...
Population genetics OMIM Koga et al. (1998) stated that OPLL is recognized as a common disorder among Japanese and throughout Asia. Estimates of its prevalence are in the range of 1.9 to 4.3%.