Sebaceous gland hyperplasia presents as one or more elevated, soft, yellow papules with central umbilication on the face, particularly the forehead. Lesions may spread to the neck and upper part of the thorax. Sebaceous gland hyperplasia occurs frequently ... Sebaceous gland hyperplasia presents as one or more elevated, soft, yellow papules with central umbilication on the face, particularly the forehead. Lesions may spread to the neck and upper part of the thorax. Sebaceous gland hyperplasia occurs frequently in older individuals, particularly in men past middle age (Nomland, 1930). A premature form has its appearance during puberty or just afterwards, male predominance, and excessive sebaceous secretion. Most cases are sporadic (summary by Boonchai and Leenutaphong, 1997).
Dupre et al. (1980) described 2 brothers with premature sebaceous gland hyperplasia of the face with onset during puberty. The disorder showed slow progression and a confluence of lesions resulted in the formation of large plaques on the ... Dupre et al. (1980) described 2 brothers with premature sebaceous gland hyperplasia of the face with onset during puberty. The disorder showed slow progression and a confluence of lesions resulted in the formation of large plaques on the face with excessive sebaceous secretion. De Villez and Roberts (1982) and Bhawan and Calhoun (1983) described sporadic cases of presenile sebaceous gland hyperplasia. Boonchai and Leenutaphong (1997) described a Thai family with premature sebaceous gland hyperplasia similar to that reported by Dupre et al. (1980) in 5 consecutive generations. There were 6 instances of male-to-male transmission. Weisshaar et al. (1999) described a family with familial nevoid sebaceous gland hyperplasia in 3 consecutive generations. All the patients were successfully treated with oral isotretinoin.