DIABETES MELLITUS, TRANSIENT NEONATAL, 1

General Information (adopted from Orphanet):

Synonyms, Signs: DMTN
TNDM1
TNDM
Number of Symptoms 6
OrphanetNr:
OMIM Id: 601410
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0008255) Transient neonatal diabetes mellitus 3 / 7739
2
(HPO:0001511) Intrauterine growth retardation 358 / 7739
3
(HPO:0001525) Severe failure to thrive 13 / 7739
4
(HPO:0003074) Hyperglycemia 37 / 7739
5
(HPO:0001944) Dehydration 59 / 7739
6
(OMIM) Insulin therapy usually required 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Neonatal diabetes mellitus (NDM), defined as insulin-requiring hyperglycemia within the first month of life, is a rare entity, with an estimated incidence of 1 in 400,000 neonates (Shield, 2000). In about half of the neonates, diabetes is transient ...
Clinical Description OMIM Temple et al. (1996) reviewed the manifestations of transient neonatal diabetes mellitus and the evidence for an imprinted, paternally expressed gene on chromosome 6q22-q23. They reported that TNDM occurs with a frequency of approximately 1 in 500,000 births. ...
Genotype-Phenotype Correlations OMIM In a study of 97 patients with diabetes diagnosed in the first 6 months of life whose diabetes remitted before the age of 5 years, 64 of whom had previously been reported, Flanagan et al. (2007) found that ...
Molecular genetics OMIM On the basis of selection under the twin criteria of involvement in DNA binding or transcription regulation and expression in mouse oocyte or early zygote, and because of its expression in undifferentiated stem cell lineages and downregulation upon ...