PITUITARY ADENOMA, PROLACTIN-SECRETING

General Information (adopted from Orphanet):

Synonyms, Signs: PROLACTINOMA, FAMILIAL
Number of Symptoms 2
OrphanetNr:
OMIM Id: 600634
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0006767) Pituitary prolactin cell adenoma 3 / 7739
2
(MedDRA:10036832) Prolactinoma 5 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Prolactin-secreting pituitary adenoma, or prolactinoma, is the most common type of hormonally active pituitary adenoma. These tumors can also be seen as a feature of multiple endocrine neoplasia type I (MEN1; 131100).

See also 102200 for ...

Clinical Description OMIM Berezin and Karasik (1995) studied 4 families in each of which more than one member was found to have prolactinoma. They concluded that there is a familial tendency to prolactinoma independent of its association with MEN1.
Molecular genetics OMIM In affected individuals from a large Finnish kindred with pitiutary adenoma predisposition (PAP; see 102200), Vierimaa et al. (2006) identified a mutation in the AIP gene (Q14X; 605555.0001). Five individuals had prolactinomas, 4 had somatotropinomas, and 2 had ...