Prolactin-secreting pituitary adenoma, or prolactinoma, is the most common type of hormonally active pituitary adenoma. These tumors can also be seen as a feature of multiple endocrine neoplasia type I (MEN1; 131100).
See also 102200 for ... Prolactin-secreting pituitary adenoma, or prolactinoma, is the most common type of hormonally active pituitary adenoma. These tumors can also be seen as a feature of multiple endocrine neoplasia type I (MEN1; 131100). See also 102200 for a discussion of familial isolated pituitary adenoma (FIPA) and acromegaly due to a growth hormone (GH; 139250)-secreting pituitary adenoma, which are also caused by mutation in the AIP gene. Schlechte (2003) discussed prolactinoma in general terms as a clinical, diagnostic, and therapeutic problem.
Berezin and Karasik (1995) studied 4 families in each of which more than one member was found to have prolactinoma. They concluded that there is a familial tendency to prolactinoma independent of its association with MEN1.
In affected individuals from a large Finnish kindred with pitiutary adenoma predisposition (PAP; see 102200), Vierimaa et al. (2006) identified a mutation in the AIP gene (Q14X; 605555.0001). Five individuals had prolactinomas, 4 had somatotropinomas, and 2 had ... In affected individuals from a large Finnish kindred with pitiutary adenoma predisposition (PAP; see 102200), Vierimaa et al. (2006) identified a mutation in the AIP gene (Q14X; 605555.0001). Five individuals had prolactinomas, 4 had somatotropinomas, and 2 had a mixed tumor comprising both cells. Daly et al. (2007) identified mutations in the AIP gene in affected individuals from 3 unrelated families with pituitary adenomas in which at least 1 member had a prolactinoma. Affected relatives of these patients had GH-secreting adenomas or nonsecreting adenomas.