Oncocytomas are usually benign tumors that occur in various organs but particularly in the kidneys. Histologic evaluation of renal oncocytomas shows that they are composed entirely of peculiar epithelial cells with granular eosinophilic cytoplasm. Ultrastructural characterization exhibits densely ... Oncocytomas are usually benign tumors that occur in various organs but particularly in the kidneys. Histologic evaluation of renal oncocytomas shows that they are composed entirely of peculiar epithelial cells with granular eosinophilic cytoplasm. Ultrastructural characterization exhibits densely packed cells with mitochondria, which show morphologic differences from those in normal cells. On the average they are larger than those in renal carcinoma cells and their shape is abnormal (summary by Welter et al., 1989).
Weirich et al. (1998) described 5 families in which multiple members had multiple bilateral renal oncocytomas. On dermatologic examination by Toro et al. (1999), 13 members of 3 of these families were found to have cutaneous lesions of ... Weirich et al. (1998) described 5 families in which multiple members had multiple bilateral renal oncocytomas. On dermatologic examination by Toro et al. (1999), 13 members of 3 of these families were found to have cutaneous lesions of Birt-Hogg-Dube syndrome (135150).
Bartoletti-Stella et al. (2011) stained an oncocytic tumor of the adnexal lacrimal glands of the conjunctiva with a specific antibody against complex V(6) and observed mitochondrial abundance in the neoplastic cells. Analysis of the entire mtDNA sequence revealed ... Bartoletti-Stella et al. (2011) stained an oncocytic tumor of the adnexal lacrimal glands of the conjunctiva with a specific antibody against complex V(6) and observed mitochondrial abundance in the neoplastic cells. Analysis of the entire mtDNA sequence revealed a frameshift mutation in MTND6 (516006.0009) in tumor cells. Ki67 staining revealed a low proliferation index of 1.8%, consistent with the benign nature of the case.