Salleras and Ortiz de Zarate (1950) reported a family showing X-linked inheritance of external ophthalmoplegia and myopia. Affected men showed bilateral ptosis, complete or partial ophthalmoplegia, abnormal shape or function of the pupil, myopia, and progressive degeneration of ... Salleras and Ortiz de Zarate (1950) reported a family showing X-linked inheritance of external ophthalmoplegia and myopia. Affected men showed bilateral ptosis, complete or partial ophthalmoplegia, abnormal shape or function of the pupil, myopia, and progressive degeneration of the retina and choroid. Often there was also absence of patellar and Achilles reflexes, spina bifida, and cardiac and other congenital malformations. Some carrier women showed absent deep tendon reflexes only. The pedigree was brought up to date by Ortiz de Zarate (1966).