In 3 males in 2 generations and 3 sibships, related through females, Chaganti and German (1979) observed infertility. Testicular tissue from the propositus showed desynapsis, lack of chiasmata and degeneration of spermatocytes during the first meiotic division. X-linked ... In 3 males in 2 generations and 3 sibships, related through females, Chaganti and German (1979) observed infertility. Testicular tissue from the propositus showed desynapsis, lack of chiasmata and degeneration of spermatocytes during the first meiotic division. X-linked recessive and male-limited autosomal dominant inheritance were considered possibilities. (See 258150 for evidence of an autosomal recessive defect.) 'Bare patches' (Bpa) in mice is a semidominant X-linked trait associated with high frequency of XO females.