Malekpour et al. (2007) described 5 Iranian brothers, born of healthy first-cousin Kurdish parents, who had late-onset progressive hearing loss, posterior subcapsular cataract, pigmentary changes consistent with retinitis pigmentosa, and a spectrum of sperm abnormalities. The 2 unaffected ... Malekpour et al. (2007) described 5 Iranian brothers, born of healthy first-cousin Kurdish parents, who had late-onset progressive hearing loss, posterior subcapsular cataract, pigmentary changes consistent with retinitis pigmentosa, and a spectrum of sperm abnormalities. The 2 unaffected sisters in the family had no hearing, vision, or fertility problems. All of the brothers first noted hearing loss at 18 or 19 years of age, followed by rapid progression to profound deafness within 5 to 6 years; vestibular reflexes were normal. All had posterior subcapsular cataract, and 2 brothers had undergone intraocular lens replacement surgery; all had pigmentary changes of the retina noted upon examination. Two of the brothers were infertile, and examination of sperm revealed misshapen sperm with impaired motility to varying degrees in all 5 brothers.