GRAVES DISEASE, SUSCEPTIBILITY TO, 1

General Information (adopted from Orphanet):

Synonyms, Signs: THYROTOXICOSIS
HYPERTHYROIDISM, AUTOIMMUNE GRAVES DISEASE, SUSCEPTIBILITY TO, 1, INCLUDED
GRD1, INCLUDED
GRD
Number of Symptoms 21
OrphanetNr:
OMIM Id: 275000
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
 (HPO:0000520) Proptosis 192 / 7739
2
 (HPO:0000737) Irritability 93 / 7739
3
 (HPO:0002591) Polyphagia 25 / 7739
4
 (HPO:0001347) Hyperreflexia 363 / 7739
5
 (HPO:0000752) Hyperactivity 140 / 7739
6
 (HPO:0100647) Graves disease 1 / 7739
7
 (HPO:0000836) Hyperthyroidism 25 / 7739
8
 (HPO:0000853) Goiter 39 / 7739
9
 (HPO:0001438) Abnormality of the abdomen 28 / 7739
10
 (HPO:0001824) Weight loss 42 / 7739
11
 (HPO:0200028) Pretibial myxedema 1 / 7739
12
 (HPO:0000975) Hyperhidrosis 64 / 7739
13
 (HPO:0001806) Onycholysis 20 / 7739
14
 (HPO:0001722) High-output congestive heart failure 4 / 7739
15
 (HPO:0001635) Congestive heart failure 232 / 7739
16
 (HPO:0001939) Abnormality of metabolism/homeostasis 328 / 7739
17
 (HPO:0001324) Muscle weakness 859 / 7739
18
 (OMIM) GI hypermotility 1 / 7739
19
 (OMIM) Low serum TSH 1 / 7739
20
 (OMIM) High T4 and T3 1 / 7739
21
 (OMIM) High RAI 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Graves disease is an autoimmune disorder in which antibodies to the thyrotropin receptor (TSHR; 603372) result in constitutive activation of the receptor and increased levels of thyroid hormone. Wilkin (1990) reviewed endocrine disorders of hormone excess and hormone ...