TARDIVE DYSKINESIA

General Information (adopted from Orphanet):

Synonyms, Signs:
Number of Symptoms 12
OrphanetNr:
OMIM Id: 272620
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal recessive inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000707) Abnormality of the nervous system 61 / 7739
2
(OMIM) Oral-lingual-buccal dyskinesia 1 / 7739
3
(OMIM) Body-rocking 1 / 7739
4
(HPO:0040141) Tardive dyskinesia 1 / 7739
5
(OMIM) Tongue darting 1 / 7739
6
(OMIM) Marching-in-place 1 / 7739
7
(OMIM) Chewing movements 1 / 7739
8
(OMIM) Repetitive rapid body movements 1 / 7739
9
(OMIM) Finger and toe movements 1 / 7739
10
(HPO:0000007) Autosomal recessive inheritance 2538 / 7739
11
(MedDRA:10043118) Tardive dyskinesia 1 / 7739
12
(MedDRA:10001540) Akathisia 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is ...
Clinical Description OMIM In a review, Thelma et al. (2008) noted that age and African American ethnicity are both risk factors for the development of tardive dyskinesia.
Molecular genetics OMIM Thelma et al. (2008) provided a review of the genetic studies of tardive dyskinesia. Although none of the findings satisfied strict criteria for significant associations, genes implicated in drug metabolism (e.g., CYP2D6; 124030) and the dopaminergic pathway (e.g., ...