Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is ... Tardive dyskinesia is a debilitating motor disorder manifest as hyperkinetic, involuntary, repetitive movements predominantly of the orofacial region. It is a complication of treatment with so-called typical antipsychotic or neuroleptic agents, such as chlorpromazine or haloperidol, and is estimated to occur in 20 to 30% of chronic schizophrenics on long-term treatment (Thelma et al., 2008).
Thelma et al. (2008) provided a review of the genetic studies of tardive dyskinesia. Although none of the findings satisfied strict criteria for significant associations, genes implicated in drug metabolism (e.g., CYP2D6; 124030) and the dopaminergic pathway (e.g., ... Thelma et al. (2008) provided a review of the genetic studies of tardive dyskinesia. Although none of the findings satisfied strict criteria for significant associations, genes implicated in drug metabolism (e.g., CYP2D6; 124030) and the dopaminergic pathway (e.g., DRD2; 126450) showed promising initial results.