LIPODYSTROPHY, CONGENITAL GENERALIZED, TYPE 2
General Information (adopted from Orphanet):
Synonyms, Signs: |
LIPOATROPHIC DIABETES, CONGENITAL BERARDINELLI SYNDROME BRUNZELL SYNDROME, BSCL2-RELATED LIPODYSTROPHY, TOTAL, AND ACROMEGALOID GIGANTISM LIPODYSTROPHY, BERARDINELLI-SEIP CONGENITAL, TYPE 2 SEIP SYNDROME BERARDINELLI-SEIP CONGENITAL LIPODYSTROPHY, TYPE 2 CGL2 |
Number of Symptoms | 42 |
OrphanetNr: | |
OMIM Id: |
269700
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ICD-10: |
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UMLs: |
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MeSH: |
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MedDRA: |
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Snomed: |
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Prevalence, inheritance and age of onset:
Prevalence: | No data available. |
Inheritance: |
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Age of onset: |
Congenital onset [Omim] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
AARSKOG SYNDROME, AUTOSOMAL DOMINANT
-AARSKOG SYNDROME, AUTOSOMAL DOMINANT |
Comment:
Monogenic form of diabetes caused by mutations in BSCL2 (PMID:21127150) |
Symptom Information:
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(HPO:0000057) | Clitoromegaly | 30 / 7739 | ||||
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(HPO:0000147) | Polycystic ovaries | 18 / 7739 | ||||
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(HPO:0000138) | Ovarian cyst | 25 / 7739 | ||||
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(HPO:0000144) | Decreased fertility | 11 / 7739 | ||||
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(HPO:0008675) | Enlarged polycystic ovaries | 14 / 7739 | ||||
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(HPO:0000065) | Labial hypertrophy | 4 / 7739 | ||||
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(HPO:0000868) | Decreased fertility in females | 3 / 7739 | ||||
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(HPO:0000303) | Mandibular prognathia | 179 / 7739 | ||||
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(HPO:0001256) | Intellectual disability, mild | 141 / 7739 | ||||
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(HPO:0002591) | Polyphagia | 25 / 7739 | ||||
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(HPO:0000877) | Insulin-resistant diabetes mellitus at puberty | 2 / 7739 | ||||
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(HPO:0000842) | Hyperinsulinemia | 39 / 7739 | ||||
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(HPO:0003292) | Decreased serum leptin | 3 / 7739 | ||||
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(HPO:0002833) | Cystic angiomatosis of bone | 3 / 7739 | ||||
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(HPO:0001169) | Broad palm | 43 / 7739 | ||||
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(HPO:0001769) | Broad foot | 31 / 7739 | ||||
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(HPO:0004233) | Advanced ossification of carpal bones | 14 / 7739 | ||||
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(HPO:0001176) | Large hands | 43 / 7739 | ||||
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(HPO:0001230) | Broad metacarpals | 17 / 7739 | ||||
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(HPO:0001833) | Long foot | 33 / 7739 | ||||
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(HPO:0005616) | Accelerated skeletal maturation | 46 / 7739 | ||||
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(HPO:0001744) | Splenomegaly | 337 / 7739 | ||||
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(HPO:0001544) | Prominent umbilicus | 4 / 7739 | ||||
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(HPO:0001394) | Cirrhosis | 102 / 7739 | ||||
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(HPO:0001735) | Acute pancreatitis | 6 / 7739 | ||||
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(HPO:0002240) | Hepatomegaly | 467 / 7739 | ||||
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(HPO:0001397) | Hepatic steatosis | 75 / 7739 | ||||
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(HPO:0001537) | Umbilical hernia | 206 / 7739 | ||||
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(HPO:0000098) | Tall stature | 74 / 7739 | ||||
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(HPO:0002230) | Generalized hirsutism | 32 / 7739 | ||||
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(HPO:0004554) | Generalized hypertrichosis | 30 / 7739 | ||||
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(HPO:0000956) | Acanthosis nigricans | 54 / 7739 | ||||
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(HPO:0000998) | Hypertrichosis | 52 / 7739 | ||||
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(HPO:0001007) | Hirsutism | 91 / 7739 | ||||
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(HPO:0001639) | Hypertrophic cardiomyopathy | 137 / 7739 | ||||
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(HPO:0002155) | Hypertriglyceridemia | 67 / 7739 | ||||
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(HPO:0003716) | Generalized muscular appearance from birth | 2 / 7739 | ||||
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(HPO:0009125) | Lipodystrophy | 54 / 7739 | ||||
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(HPO:0009064) | Generalized lipodystrophy | 17 / 7739 | ||||
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(HPO:0003809) | Nearly complete absence of metabolically active adipose tissue (subcutaneous, intraabdominal, intrathoracic) | 2 / 7739 | ||||
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(OMIM) | Large feet | 12 / 7739 | ||||
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(OMIM) | Nearly complete absence of mechanical adipose tissue (joints, orbits, palms, soles) | 1 / 7739 |
Associated genes:
BSCL2 |
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
Description: (OMIM) |
Congenital generalized lipodystrophy (CGL), also known as Berardinelli-Seip syndrome, is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes (Garg, 2004). For a general ... |
Clinical Description OMIM |
Van Maldergem et al. (2002) studied 70 affected individuals from 44 unrelated families with congenital generalized lipodystrophy. Forty-five patients from 24 families had BSCL2 and 21 patients from 17 families had BSCL1 (608594). Two European families had no BSCL2 ... |
Molecular genetics OMIM |
In chromosome 11q13-linked families with congenital generalized lipodystrophy type 2, and in 3 isolated patients, Magre et al. (2001) identified mutations in the BSCL2 gene (606158.0001-606158.0012). Affected individuals were either homozygous for a specific mutation or compound heterozygous; all ... |
Population genetics OMIM |
Gedde-Dahl et al. (1996) stated that 5 of the 6 families studied by Seip and Trygstad (1996) came from adjacent rural 'municipalities' of southwestern Norway. Six patients from this area were born between 1951 and 1973, and none between ... |