In a highly inbred, predominantly Cree Indian community in northern Saskatchewan, Canada, 14 similarly malformed babies were 'born to' 8 different mothers (Ives and Houston, 1980). The features were intrauterine growth retardation, perinatal death, marked microcephaly, and severe ... In a highly inbred, predominantly Cree Indian community in northern Saskatchewan, Canada, 14 similarly malformed babies were 'born to' 8 different mothers (Ives and Houston, 1980). The features were intrauterine growth retardation, perinatal death, marked microcephaly, and severe malformation of the limbs, especially the arms. Elbows were fused, forearms were greatly shortened and usually contained only a single bone, and the hands were abnormal with only 2 to 4 malformed digits. Recessive inheritance was indicated by parental consanguinity, sex ratio close to 1, and a 25% segregation ratio.