Search Results for "MTOR" - 210 interactions found in 69 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
598
12911 high-phytoestrogen soy-based diet affects_phosphorylation of MTOR at Ser2448 of MTOR
18420492 Diabetes mellitus, type II
Obesity
Insulin resistance
964
6117 MTOR increases_phosphorylation of IRS1 at Ser312 of IRS1
6149 MTOR increases_phosphorylation of IRS1 at Ser636 of IRS1
19041393 Diabetes mellitus, type II
Obesity
Insulin resistance
966
5969 AKT1 increases_phosphorylation of MTOR
5971 MTOR NOT affects_activity of cell death
15339911 Amyotrophic lateral sclerosis
1,467
10360 MTOR affects_activity of IL6 in liver
10442 IL6 increases_activity of MTOR in liver
10443 MTOR increases_activity of STAT3 in liver
10444 MTOR increases_phosphorylation of STAT3 in liver; at Ser727 of STAT3
10448 MTOR increases_expression of SOCS3 in liver
17993646 Diabetes mellitus, type II
Insulin resistance
2,146
17903 Metabolic syndrome decreases_quantity of MTOR
17907 MTOR affects_activity of thrombosis
20809949 Diabetes mellitus, type II
Insulin resistance
Metabolic syndrome
2,814
26005 AKT1 increases_activity of MTOR
26020 TSC1-TSC2 complex decreases_activity of MTOR
26021 MTOR increases_activity of RPS6KB1
26022 MTOR increases_activity of EIF4EBP1
26023 MTOR increases_activity of translation
26028 AMPK decreases_activity of MTOR
26037 MTOR affects_activity of Cancer
26038 response to hypoxia decreases_activity of MTOR
26052 MTOR decreases_activity of Trastuzumab
26053 MTOR decreases_activity of Tamoxifen
26091 TNF decreases_activity of MTOR
21912508 Diabetes mellitus, type II
Cancer
Insulin resistance
Metabolic syndrome
2,843
26210 Metformin decreases_activity of MTOR
26222 AMPK decreases_activity of MTOR
26223 MTOR increases_activity of translational initiation
18006825 Diabetes mellitus, type II
Cancer
Insulin resistance
2,844
26218 AMPK decreases_activity of MTOR
18006825 Diabetes mellitus, type II
Cancer
Insulin resistance
2,845
26220 TSC1-TSC2 complex affects_activity of MTOR
18006825 Diabetes mellitus, type II
Cancer
Insulin resistance
2,897
26612 Metformin decreases_activity of MTOR
19221498 Breast cancer
Diabetes mellitus, type II
Insulin resistance
2,904
26634 AMPK decreases_activity of MTOR
17062558 Breast cancer
Diabetes mellitus, type II
Insulin resistance
3,513
32784 high-fat diet supplemented with BCAA increases_phosphorylation of MTOR
19356713 Diabetes mellitus, type II
Obesity
Insulin resistance
3,659
35006 Phosphatidate increases_activity of MTOR
22108437 Diabetes mellitus, type II
Insulin resistance
3,795
37740 RHEB interacts (colocalizes) with MTOR
18765678 Diabetes mellitus, type II
Insulin resistance
3,853
38669 UBQLN1 interacts (colocalizes) with MTOR
20074050 Alzheimer disease
Huntington disease
4,285
46105 Olanzapine increases_activity of MTOR via phosphorylation at Ser248
23926289 Diabetes mellitus, type II
Schizophrenia
Insulin resistance
4,309
44140 MTOR increases_activity of POU5F1 OCT-4: marker for pluripotency
44141 MTOR increases_activity of SOX2 SOX2: marker for pluripotency
44142 MTOR increases_activity of NANOG NANOG: marker for pluripotency
44143 MTOR decreases_activity of endoderm
44144 MTOR decreases_activity of mesoderm
44145 MTOR affects_activity of embryonic stem cell concerning the proliferation
44146 MTOR affects_activity of stem cell proliferation of human embryonic stem cells (hESC)
44147 MTOR increases_activity of stem cell division of human embryonic stem cells
44148 MTOR decreases_expression of TBXT if mTOR is activated up-regulation of T gene is repressed
44149 MTOR affects_expression of MIXL1 inhibition of mTOR results in an up-regulation of MIXL1
44158 MTOR decreases_expression of MESP1 if mTOR is activated up-regulation of MESP1 is repressed
44162 MTOR decreases_expression of GATA4 if mTOR is activated up-regulation of GATA4 is repressed
44163 MTOR decreases_expression of GATA6 if mTOR is activated up-regulation of GATA6 is repressed
44166 MTOR decreases_expression of EOMES if mTOR is activated up-regulation of EOMES is repressed
44167 MTOR decreases_expression of SOX17 if mTOR is activated up-regulation of SOX17 is repressed
44168 MTOR affects_expression of EBF2 inhibition of mTOR results in an up-regulation of EBF2
44169 MTOR affects_expression of PITX2 inhibition of mTOR results in an up-regulation of PITX2
44220 MTOR affects_expression of CCNG2 Cyclin G2 is a downstream target of mTOR in hESCs and regulates cell proliferation.
44221 MTOR affects_expression of PDCD4 PDCD4 is a downstream target of mTOR in hESCs and regulates cell proliferation.
44235 Rapamycin decreases_activity of MTOR
44903 MTOR decreases_activity of canonical Wnt signaling pathway in H9 cells
19416884 Metabolic
4,409
44811 canonical Wnt signaling pathway increases_activity of MTOR synaptic stimulation of mTOR is mediated by Wnt signaling
44812 AKT1 interacts (colocalizes) with MTOR mediated by phosphorylated GSK3A
44815 GSK3B decreases_activity of MTOR GSK3 is regulated by the Wnt signaling pathway
44817 canonical Wnt signaling pathway affects_activity of MTOR
44925 TSC2 decreases_activity of MTOR
49776 MTOR is_part_of AKT1-MTOR complex
22131415 Metabolic
5,301
52000 PPARGC1A increases_activity of MTOR in skeletal muscle; via increased phosphorylation
19918075 Diabetes mellitus, type II
Insulin resistance
5,315
51956 MTOR is_part_of mTORC1 complex
51959 MTOR is_part_of mTORC2 complex
51961 Torin1 decreases_activity of MTOR
19150980 Metabolic
5,424
52955 Streptozocin-induced diabetes NOT affects_expression of MTOR
22524197 Diabetes mellitus, type II
Diabetes mellitus, type I
Insulin resistance
Cardiomyopathy, diabetic
5,448
53181 MSDC-0160 decreases_activity of MTOR in pancreas, in pancreatic islets
23650507 Diabetes mellitus, type II
Insulin resistance
5,451
53203 MTOR increases_phosphorylation of IRS1 statin-induced
17121917 Metabolic
5,452
53216 MTOR affects_activity of autophagy
20639871 Metabolic
5,493
53398 MTOR increases_expression of CTNNB1 in HepG2 and Hep3B cells
21239045 Cancer
Metabolic
6,191
57836 Vorinostat decreases_phosphorylation of MTOR
23147569 Cancer
6,192
57841 FC85 decreases_phosphorylation of MTOR in glioblastoma multiforme cells; at Ser2448
25898313 Glioblastoma
Cancer
6,204
58176 MTOR affects_activity of PI3K/TOR signaling
58181 MTOR affects_activity of TOR/S6K1 signaling
59412 MTOR increases_phosphorylation of HDAC1 in MCF7 cells
25801958 Breast cancer
6,205
58216 Triciribine NOT decreases_phosphorylation of MTOR
58218 Rapamycin decreases_activity of MTOR
58223 MTOR affects_activity of NFKB1 if MTOR is activated, by modulating NF-kappaBp50 transcriptional activity.
58224 HDAC2 increases_activity of MTOR in liver cancer; by stabilization of mTOR, if HDAC2 expression is elevated.
58382 EGF increases_phosphorylation of MTOR in hepatocellular carcinoma cells
58384 MTOR increases_expression of HDAC2 in hepatocellular carcinoma cells; if mTOR is EGF stimulated.
58388 LY 294002 decreases_phosphorylation of MTOR if mTOR is EGF-stimulated.
58393 EGF increases_activity of MTOR
58399 MTOR affects_activity of PI3K/TOR signaling
58419 MTOR affects_activity of TORC1/NFKB1 signaling
24448241 Hepatocellular carcinoma
Cancer
6,206
58410 Temsirolimus decreases_activity of MTOR
23866964 Burkitt lymphoma
Cancer
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