Search Results for "LPIN1" - 219 interactions found in 19 entries.

Entry-ID
Interactor1 (Subject) Interaction type Interactor2 (Object) additional information
PubMed-ID
Diseases
664
3590 LPIN1 is localized in cytoplasm associated with endoplasmic reticulum membrane
3602 LPIN1 interacts (colocalizes) with endoplasmic reticulum membrane
3603 LPIN1 affects_activity of triglyceride biosynthetic process
3665 Streptozocin-induced diabetes decreases_activity of LPIN1
3675 decreased activity of thyroid gland decreases_activity of LPIN1
3721 Glucagon decreases_activity of LPIN1 in liver; by translocation of PPH-1 to cytosol
3722 cAMP decreases_activity of LPIN1 in liver; by translocation of PPH-1 to cytosol
10940327 Diabetes mellitus, type II
Diabetes mellitus, type I
Insulin resistance
Hypothyroidism
736
4124 LPIN1 is_expressed_in white adipose tissue
4220 LPIN1 affects_activity of fat cell differentiation
4221 LPIN1 increases_expression of PPARG
4222 LPIN1 increases_expression of CEBPA
4223 LPIN1 decreases_expression of DLK1
4238 LPIN1 affects_activity of Lipodystrophy
4239 LPIN1 affects_activity of Obesity
4241 LPIN1 affects_expression of ACACA
4243 LPIN1 affects_quantity of Triacylglycerol in adipose tissue
4244 LPIN1 affects_activity of increased susceptibility to weight gain
4245 LPIN1 affects_activity of fatty acid beta-oxidation in muscle
4247 LPIN1 affects_activity of Insulin resistance in muscle
4248 Diabetes mellitus, type II increases_expression of LPIN1 in muscle
4249 prolonged fasting increases_expression of LPIN1 in muscle
4250 cachexia increases_expression of LPIN1 in muscle
4251 uremia increases_expression of LPIN1 in muscle
4252 Insulin resistance affects_expression of LPIN1 in adipose tissue
4269 LPIN1 affects_activity of increased insulin sensitivity
4270 LPIN1 NOT affects_activity of Obesity
4271 LPIN1 affects_expression of SLC2A4 in adipose tissue
4273 Thiazolidinedione increases_expression of LPIN1 in adipose tissue
4280 Harmine increases_expression of LPIN1 in adipose tissue
4297 Mg2+ affects_activity of LPIN1
4298 LPIN1 is localized in cytoplasm
4299 LPIN1 is localized in nucleus
4301 LPIN1 decreases_activity of fatty acid beta-oxidation during fasting, via interaction of LPIN1 with PGC1A and PPARA
4302 LPIN1 is localized in cytoplasm
4309 Diabetes mellitus, type II increases_activity of LPIN1 in liver
4310 response to hypoxia increases_activity of LPIN1 in liver
4311 Fatty liver disease, nonalcoholic increases_activity of LPIN1 in liver
4312 Glucocorticoid increases_activity of LPIN1 in liver; if glucocorticoids are elevated
4313 Diabetes mellitus, type II decreases_activity of LPIN1 in adipose tissue
4314 fasting decreases_activity of LPIN1 in adipose tissue
4319 Insulin increases_phosphorylation of LPIN1
4321 TOR signaling increases_phosphorylation of LPIN1 at Ser106 of LPIN1; if insulin-stimulated
4322 Adrenaline decreases_phosphorylation of LPIN1
4323 Oleic acid decreases_phosphorylation of LPIN1
4324 phosphorylation NOT affects_activity of LPIN1
4325 Polyunsaturated fatty acid increases_expression of LPIN1 in liver
4326 circadian rhythm affects_expression of LPIN1
13082 Fatty acid increases_transport of LPIN1 to ER membrane
13083 Acyl-CoA increases_transport of LPIN1 to ER membrane
45619 LPIN1 is_expressed_in brown adipose tissue
45620 LPIN1 is_expressed_in skeletal muscle
45621 LPIN1 is_expressed_in testis
45622 LPIN1 is_expressed_in liver
45623 LPIN1 is_expressed_in peripheral nerve
45624 LPIN1 is_expressed_in brain
45625 LPIN1 is_expressed_in kidney
45626 LPIN1 is_expressed_in pancreatic beta cell
45632 phosphorylation affects transport of LPIN1
18023282 Diabetes mellitus, type II
Obesity
Lipodystrophy
Insulin resistance
Fatty liver disease, nonalcoholic
Majeed syndrome
787
4401 fasting increases_expression of LPIN1 in wild-type, but not in PGC-1alpha -/- mice
4403 PPARGC1A increases_quantity of LPIN1 if PPARGC1A is overexpressed
4410 LPIN1 increases_expression of PPARA
4423 LPIN1 increases_activity of fatty acid import
4425 LPIN1 increases_activity of fatty acid metabolic process
4427 LPIN1 decreases_activity of fatty acid biosynthetic process if LPIN1 is overexpressed
4429 LPIN1 decreases_activity of triglyceride biosynthetic process if LPIN1 is overexpressed
4430 LPIN1 increases_expression of CPT1A if LPIN1 is overexpressed
4433 LPIN1 increases_expression of ACADVL if LPIN1 is overexpressed
4434 LPIN1 increases_expression of ACADM if LPIN1 is overexpressed
4435 LPIN1 increases_expression of ACOX1 if LPIN1 is overexpressed
4436 LPIN1 increases_expression of FABP1 if LPIN1 is overexpressed
4437 LPIN1 increases_activity of tricarboxylic acid cycle if LPIN1 is overexpressed
4438 LPIN1 increases_expression of SDHA if LPIN1 is overexpressed
4439 LPIN1 increases_expression of IDH3A if LPIN1 is overexpressed
4440 LPIN1 increases_expression of MDH2 if LPIN1 is overexpressed
4441 LPIN1 affects_activity of regulation of mitochondrial metabolism if LPIN1 is overexpressed
4442 LPIN1 increases_expression of TFAM if LPIN1 is overexpressed
4445 LPIN1 increases_activity of oxidative phosphorylation if LPIN1 is overexpressed
4447 LPIN1 increases_expression of CYCS if LPIN1 is overexpressed
4450 LPIN1 increases_expression of MT-CO2 if LPIN1 is overexpressed
4453 LPIN1 increases_expression of ATP5F1B if LPIN1 is overexpressed
4458 LPIN1 decreases_activity of lipid biosynthetic process if LPIN1 is overexpressed
4463 LPIN1 decreases_expression of SREBF1 if LPIN1 is overexpressed
4464 LPIN1 decreases_expression of FASN if LPIN1 is overexpressed
4465 LPIN1 decreases_activity of fatty acid desaturation if LPIN1 is overexpressed
4466 LPIN1 decreases_expression of SCD if LPIN1 is overexpressed
4467 LPIN1 decreases_activity of lipoprotein secretion if LPIN1 is overexpressed
4468 LPIN1 decreases_expression of APOA4 if LPIN1 is overexpressed
4469 LPIN1 increases_activity of palmitate oxidation if LPIN1 is overexpressed
4471 LPIN1 increases_activity of fatty acid beta-oxidation if LPIN1 is overexpressed
4472 LPIN1 increases_quantity of (R)-3-Hydroxybutanoate in blood; if LPIN1 is overexpressed
4486 LPIN1 affects_expression of CPT1A
4487 LPIN1 affects_expression of ACADVL
4488 LPIN1 affects_expression of ACADL
4489 LPIN1 affects_expression of ACADM
4490 LPIN1 affects_expression of FABP1
4491 LPIN1 affects_expression of APOA4
4493 LPIN1 interacts (colocalizes) with PPARA
4494 LPIN1 interacts (colocalizes) with PPARD
4495 LPIN1 interacts (colocalizes) with HNF4A
4496 LPIN1 interacts (colocalizes) with NR3C1
4497 LPIN1 NOT interacts (colocalizes) with ESRRA
4498 LPIN1 affects_activity of regulation of fatty acid beta-oxidation
4499 LPIN1 interacts (colocalizes) with PPARGC1A
4500 LPIN1 increases_activity of PPARGC1A
4501 LPIN1 increases_activity of fatty acid beta-oxidation via PPARGC1A
4502 LPIN1 increases_expression of CPT2 if LPIN1 is overexpressed
4503 LPIN1 increases_expression of HADHA if LPIN1 is overexpressed
4504 LPIN1 increases_expression of HADH if LPIN1 is overexpressed
4505 LPIN1 increases_expression of EHHADH if LPIN1 is overexpressed
4506 LPIN1 increases_expression of SLC27A2 if LPIN1 is overexpressed
4507 LPIN1 increases_expression of SLC27A5 if LPIN1 is overexpressed
4508 LPIN1 decreases_expression of LPL if LPIN1 is overexpressed
4509 LPIN1 decreases_expression of VLDLR if LPIN1 is overexpressed
4510 LPIN1 decreases_expression of LIPE if LPIN1 is overexpressed
4511 LPIN1 decreases_expression of ACACB if LPIN1 is overexpressed
4512 LPIN1 decreases_expression of SCD5 if LPIN1 is overexpressed
4513 LPIN1 increases_expression of SDHB if LPIN1 is overexpressed
4514 LPIN1 increases_expression of SDHC if LPIN1 is overexpressed
4515 LPIN1 increases_expression of SDHD if LPIN1 is overexpressed
4516 LPIN1 increases_expression of MDH1 if LPIN1 is overexpressed
4517 LPIN1 increases_expression of IDH1 if LPIN1 is overexpressed
4518 LPIN1 increases_expression of IDH3B if LPIN1 is overexpressed
4519 LPIN1 increases_expression of COX5A if LPIN1 is overexpressed
4520 LPIN1 increases_expression of COX5B if LPIN1 is overexpressed
4521 LPIN1 increases_expression of COX6B1 if LPIN1 is overexpressed
4522 LPIN1 increases_expression of COX6B2 if LPIN1 is overexpressed
4523 LPIN1 increases_expression of COX7A2 if LPIN1 is overexpressed
4524 LPIN1 increases_expression of COX8A if LPIN1 is overexpressed
4525 LPIN1 increases_expression of ETFDH if LPIN1 is overexpressed
4526 LPIN1 increases_expression of NDUFA3 if LPIN1 is overexpressed
4528 LPIN1 increases_expression of NDUFA6 if LPIN1 is overexpressed
4529 LPIN1 increases_expression of NDUFA7 if LPIN1 is overexpressed
4530 LPIN1 increases_expression of NDUFA11 if LPIN1 is overexpressed
4531 LPIN1 increases_expression of NDUFB3 if LPIN1 is overexpressed
4532 LPIN1 increases_expression of NDUFB4 if LPIN1 is overexpressed
4533 LPIN1 increases_expression of NDUFB5 if LPIN1 is overexpressed
4534 LPIN1 increases_expression of NDUFB10 if LPIN1 is overexpressed
4535 LPIN1 increases_expression of NDUFAF1 if LPIN1 is overexpressed
4536 LPIN1 increases_expression of ATP5MC2 if LPIN1 is overexpressed
4537 LPIN1 increases_expression of ATP5MF if LPIN1 is overexpressed
4538 LPIN1 increases_expression of ATP5PO if LPIN1 is overexpressed
4539 LPIN1 increases_expression of SOD1 if LPIN1 is overexpressed
4540 LPIN1 increases_expression of SOD2 if LPIN1 is overexpressed
4541 LPIN1 increases_expression of SOD3 if LPIN1 is overexpressed
13084 PPARGC1A affects_expression of LPIN1
16950137 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
824
4878 LPIN1 increases_activity of triglyceride biosynthetic process in cytoplasm
4882 LPIN1 increases_activity of phospholipid biosynthetic process in cytoplasm
4893 LPIN1 affects_activity of fatty acid beta-oxidation in nucleus
4894 LPIN1 increases_expression of PPARA in nucleus
4896 SREBF1 affects_expression of LPIN1 in nucleus
4897 NR1H increases_expression of LPIN1 in nucleus
4898 CRTC2 increases_expression of LPIN1 in nucleus
4899 LPIN1 increases_quantity of Diacylglycerol
4904 LPIN1 increases_expression of PPARGC1A
5082 LPIN1 interacts (colocalizes) with PPARG in white adipose tissue
5083 LPIN1 increases_activity of glycerol biosynthetic process from pyruvate in white adipose tissue
5088 LPIN1 increases_activity of PCK1 in white adipose tissue
5089 LPIN1 increases_activity of Obesity
5090 LPIN1 increases_quantity of Triacylglycerol in adipose tissue
5091 LPIN1 decreases_activity of Insulin resistance
5130 LPIN1 increases_quantity of VLDL
19770177 Diabetes mellitus, type II
Obesity
Insulin resistance
3,912
39709 high-fat diet supplemented with crude farmed Atlantic salmon oil decreases_expression of LPIN1 in liver, in adipose tissue
39711 Persistent organic pollutant decreases_expression of LPIN1 in liver, in adipose tissue
20064776 Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
4,462
45327 PPARGC1A increases_expression of LPIN1
17476214 Diabetes mellitus, type II
Insulin resistance
4,895
48209 Metformin decreases_expression of LPIN1 in liver
Diabetes mellitus, type II
Insulin resistance
5,286
51722 Dexamethasone increases_expression of LPIN1 in cardiac muscle
51766 cAMP increases_expression of LPIN1 in cardiac muscle
23505321 Diabetes mellitus, type II
Insulin resistance
5,287
51776 fasting NOT affects_expression of LPIN1 in cardiac muscle
23505321 Diabetes mellitus, type II
Insulin resistance
6,226
58264 TOP1 affects_expression of LPIN1
17875716 Breast cancer
Colorectal cancer
7,415
72817 LPIN1 increases_quantity of Diacylglycerol
72822 APOE KO mouse decreases_expression of LPIN1 -14.30 fold, fed with 1.25% cholesterol (high-Chol diet)
73083 LPIN1 decreases_quantity of Phosphatidate
73086 LPIN1 increases_quantity of LPIN1A by alternative splicing;
73087 LPIN1 increases_quantity of LPIN1B by alternative splicing;
73098 Glucocorticoid affects_expression of LPIN1 in liver; in apoE-KO mice, when fed with 1.25% cholesterol;
73115 PPARGC1A increases_expression of LPIN1 in liver; in ApoE-KO mice; fed with 1.25% cholesterol (high-Chol diet);
73117 Taurocholate NOT affects_expression of LPIN1 in HepG2 cells
73122 LPIN1 affects_activity of VLDL secretion in liver
73123 LPIN1 affects_activity of very-low-density lipoprotein particle assembly in liver
73124 LPIN1 increases_quantity of LPIN1C by alternative splicing;
73171 SREBF1 increases_expression of LPIN1
73172 LPIN1 increases_expression of PPARA
73173 LPIN1 increases_activity of PPARGC1A Lipin-1 functions as a coactivator of PPARGC1A and is an inducible amplifier of PPARa
21857965 Alzheimer disease
Metabolic
7,416
73880 ApoE KO mouse increases_expression of LPIN1 2.97 fold, when male ApoE-KO mice were fed an atherogenic diet supplemented with or without 2% phytosterol mixtures for 14 weeks.
136879 APOE affects_expression of LPIN1 in ApoE KO mice; 2.97 fold, when male ApoE-KO mice were fed an atherogenic diet supplemented with or without 2% phytosterol mixtures for 14 weeks.
18155511 Alzheimer disease
Metabolic
9,162
97107 lipin-1-deficient myoblast decreases_expression of LPIN1 in primary myoblasts from lipin-1-deficient patients
97112 LPIN1-mut decreases_expression of LPIN1 concerning LPIN1 mRNA, protein and enzyme activity
97120 LPIN1 affects_activity of lipid droplet concerning lipid droplet content
97121 TNF decreases_expression of LPIN1 in primary myoblasts from lipin-1-deficient patients; resulting in a prolonged two-fold down-regulation of LPIN1 mRNA expression, with both, TNFalpha + IL-1beta, treatment
97128 lipin-1-deficient myoblast decreases_activity of LPIN1 in primary myoblasts from lipin-1-deficient patients
97140 LPIN1-mut decreases_activity of LPIN1 concerning LPIN1 mRNA, protein and enzyme activity
97144 IL1B decreases_expression of LPIN1 in primary myoblasts from lipin-1-deficient patients; resulting in a prolonged two-fold down-regulation of LPIN1 mRNA expression, with both, TNFalpha + IL-1beta, treatment
97155 LPIN1 decreases_expression of ACACB in both myotubes and myoblasts; experimentally displayed via Lipin-1 deficiency
97162 LPIN1 affects_quantity of Malonyl-carnitine
97183 LPIN1 affects_quantity of lipid droplet there exist inverse relationships between LPIN1 or ACACB expression, CPT1 activity and LD accumulation
23928362 Metabolic
Inflammation
9,264
98398 LPIN1 affects_activity of lipid biosynthetic process in adipose tissue, liver, muscle, and peripheral nerves
98400 LPIN2 deficiency increases_quantity of LPIN1 in liver; elevating PAP activity, which maintained lipid homeostasis under basal conditions, but leding to diet-induced hepatic triglyceride accumulation
98403 LPIN2 affects_activity of LPIN1 in liver and aging cerebellum; lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis
98405 LPIN1 increases_activity of lipid homeostasis in adipose tissue, liver, muscle, and peripheral nerves; Lipin-1 is critical for lipid synthesis and homeostasis
98408 aging decreases_quantity of LPIN1 in lipin-2-deficient aged mice; resulting in altered cerebellar phospholipid composition
22908270 Metabolic
9,266
98435 SIRT1 increases_activity of LPIN1 in liver; deletion of SIRT1 exacerbated ethanol-mediated defects in lipid metabolism, mainly by altering the function of lipin-1
24262277 Metabolic
9,328
99319 PPARGC1A increases_expression of LPIN1 in mouse; he expression of lipin1 is induced by PGC-1alpha
99320 LPIN1 increases_activity of fatty acid beta-oxidation in mice; by inducing expression of the nuclear receptor PPARalpha
99321 LPIN1 increases_expression of CPT1A in liver of mice; when LPIN1 is overexpressed
99322 LPIN1 increases_expression of ACADVL in liver of mice; when LPIN1 is overexpressed
99323 LPIN1 increases_expression of ACADM in liver of mice; when LPIN1 is overexpressed
99324 LPIN1 increases_expression of ACOX1 in liver of mice; when LPIN1 is overexpressed
99325 LPIN1 increases_expression of FABP1 in liver of mice; when LPIN1 is overexpressed
99326 LPIN1 increases_expression of PPARA in liver of mice; when LPIN1 is overexpressed
99327 LPIN1 increases_activity of decreased circulating lipid level in mice
16950137 Metabolic
10,452
108158 LPIN1 affects_activity of mTORC1/SREBP signaling pathway LPIN1 is a key component of the mTORC1-SREBP pathway
108159 LPIN1 localization affects_activity of LPIN1 LPIN1 promotes nuclear remodeling and mediates the effects of mTORC1 on SREBP target gene, SREBP promoter activity, and nuclear SREBP protein abundance
21816276 Metabolic
10,743
109584 hepatic stellate cell activation decreases_expression of LPIN1 in activated primary Hepatic Stellate Cells (HSCs)
109586 Resveratrol increases_expression of LPIN1 in Hepatic Stellate Cells (HSCs); mRNA and protein levels
109587 TGFB1 decreases_expression of LPIN1 in TGF-beta-treated LX-2 cells; the downregulation of Lipin-1 by TGF-beta was not dependent on altered mRNA stability but rather on protein stability
109588 Resveratrol decreases_ubiquitination/sumoylation of LPIN1 in Hepatic Stellate Cells (HSCs); resveratrol blocked the polyubiquitination of Lipin-1
136256 Resveratrol increases_quantity of LPIN1 in Hepatic Stellate Cells (HSCs); mRNA and protein levels
27345520 Metabolic
13,003
124094 LPIN3 affects_expression of LPIN1
124097 LPIN1 affects_activity of Obesity
24634820 Obesity
-->