Curation of data in AlzNet-DB

Information about disease-related interactions consists of three kinds of information.

• The central information is a structured interaction between two elements (e.g. protein A activates protein B). This is also known as subject-predicate-object structure. "Subjects" and "Objects" are linked/mapped to thesauri such as EntrezGene, KEGG, OMIM, miRBase, Gene Ontology, CORUM. If a term is not available in these vocabularies, we introduce suitable terms.
  Additional information about conditions (Arg_Mod = mode) or locus (Arg_Loc) are also frequently presented.
• A textual comment allows to provide additional information about the experimental setup (e.g. concentration of a drug that was applied) and to present a more differentiated view than the structured information (e.g. the structured information is restricted to 'protein A increases_activity of protein B' whereas in the text we can specify that it is a 'significant' or a 'slight' increase of the protein activity).
• The general information consists of literature reference, organism, disease and if available tissue/cell line and gender. All information is linked to the PubMed content of the respective journal articles.

Information in AlzNet-DB is given as entries and interactions. An entry comprises one or more result/-s (interactions) from one publication. A relation is part of an entry and describes an interaction (subject-predicate-object tructure) between two elements (e.g. protein A increases_activity of protein B).