General Information:

Id: 9,686 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Reference: Jesus ICG et al.(2018) Alamandine acts via MrgD to induce AMPK/NO activation against ANG II hypertrophy in cardiomyocytes Am. J. Physiol. 314: C702-C711 [PMID: 29443552]

Interaction Information:

Comment To further investigate the signaling pathways involved in the alamandine-induced NO rise, phosphorylation of protein kinase B (Akt), a key protein involved in NO production by ANG-(1–7) was assessed. Acute alamandine treatment for 5 or 15 min had no effect on the phosphorylation of Akt on Ser473, while ANG-(1–7) significantly increased Akt Ser473 phosphorylation.
Formal Description
Interaction-ID: 102333


Angiotensin (1-7)

increases_phosphorylation of



at Ser473
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